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    Ell2 elongation factor for RNA polymerase II 2 [ Mus musculus (house mouse) ]

    Gene ID: 192657, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ell2provided by MGI
    Official Full Name
    elongation factor for RNA polymerase II 2provided by MGI
    Primary source
    MGI:MGI:2183438
    See related
    Ensembl:ENSMUSG00000001542 AllianceGenome:MGI:2183438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in snRNA transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription elongation from RNA polymerase II promoter and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including branchial arch; eye; inner ear; limb ectoderm; and maxillary process. Orthologous to human ELL2 (elongation factor for RNA polymerase II 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 25.8), liver E14.5 (RPKM 21.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ell2 in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (75855603..75920480)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (75707484..75772361)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700037F03 gene Neighboring gene ribosomal protein L37a pseudogene Neighboring gene microRNA 682 Neighboring gene predicted gene, 23012 Neighboring gene predicted gene, 23127 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 41005 Neighboring gene glutaredoxin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA polymerase II elongation factor ELL2
    Names
    ELL-related RNA polymerase II, elongation factor
    eleven-nineteen lysine-rich leukemia gene 2
    elongation factor RNA polymerase II 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138953.2NP_620403.2  RNA polymerase II elongation factor ELL2

      See identical proteins and their annotated locations for NP_620403.2

      Status: VALIDATED

      Source sequence(s)
      AK145868, BE133837, CT025556
      Consensus CDS
      CCDS36734.1
      UniProtKB/Swiss-Prot
      E9QPE1, Q3UKU1
      Related
      ENSMUSP00000001583.7, ENSMUST00000001583.8
      Conserved Domains (2) summary
      pfam07303
      Location:534631
      Occludin_ELL; Occludin homology domain
      pfam10390
      Location:11289
      ELL; RNA polymerase II elongation factor ELL

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      75855603..75920480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)