Format

Send to:

Choose Destination
    • Showing Current items.

    Ptp4a2 protein tyrosine phosphatase 4a2 [ Mus musculus (house mouse) ]

    Gene ID: 19244, updated on 2-Oct-2018

    Summary

    Official Symbol
    Ptp4a2provided by MGI
    Official Full Name
    protein tyrosine phosphatase 4a2provided by MGI
    Primary source
    MGI:MGI:1277117
    See related
    Ensembl:ENSMUSG00000028788 Vega:OTTMUSG00000009511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prl-2
    Expression
    Ubiquitous expression in bladder adult (RPKM 35.0), CNS E11.5 (RPKM 30.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ptp4a2 in Genome Data Viewer
    Location:
    4; 4 D2.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (129820204..129850003)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129497723..129527247)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene predicted gene 12967 Neighboring gene RIKEN cDNA 1700108I11 gene Neighboring gene serine/arginine-rich splicing factor 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102154, MGC103400

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein tyrosine phosphatase type IVA 2
    Names
    protein-tyrosine phosphatase of regenerating liver 2
    NP_001158217.1
    NP_033000.1
    XP_006502926.1
    XP_017175534.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164745.1NP_001158217.1  protein tyrosine phosphatase type IVA 2

      See identical proteins and their annotated locations for NP_001158217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB675559, BC086794, BC087551, BY791716
      Consensus CDS
      CCDS18704.1
      UniProtKB/Swiss-Prot
      O70274
      Related
      ENSMUSP00000125901.1, ENSMUST00000165853.1
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_008974.4NP_033000.1  protein tyrosine phosphatase type IVA 2

      See identical proteins and their annotated locations for NP_033000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BB675559, BC086794, BC087551, BY110331
      Consensus CDS
      CCDS18704.1
      UniProtKB/Swiss-Prot
      O70274
      Related
      ENSMUSP00000030578.7, OTTMUSP00000009914, ENSMUST00000030578.13, OTTMUST00000021734
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      129820204..129850003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502863.3XP_006502926.1  protein tyrosine phosphatase type IVA 2 isoform X2

      See identical proteins and their annotated locations for XP_006502926.1

      Conserved Domains (1) summary
      cl21483
      Location:8132
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. XM_017320045.1XP_017175534.1  protein tyrosine phosphatase type IVA 2 isoform X1

      UniProtKB/Swiss-Prot
      O70274
      Conserved Domains (1) summary
      cl21483
      Location:8157
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187023.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1420968..1450685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center