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    Ptma prothymosin alpha [ Mus musculus (house mouse) ]

    Gene ID: 19231, updated on 19-Jul-2021

    Summary

    Official Symbol
    Ptmaprovided by MGI
    Official Full Name
    prothymosin alphaprovided by MGI
    Primary source
    MGI:MGI:97803
    See related
    Ensembl:ENSMUSG00000026238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thym
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1626.5), CNS E14 (RPKM 884.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ptma in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86454279..86458434)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86526557..86530712)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (88423311..88427273)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41907 Neighboring gene ribosomal protein L30, pseudogene 6 Neighboring gene phosphodiesterase 6D, cGMP-specific, rod, delta Neighboring gene COP9 signalosome subunit 7B Neighboring gene predicted gene, 41908

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102090, MGC103390

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360830.1NP_001347759.1  prothymosin alpha isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC158132
      Conserved Domains (1) summary
      pfam03247
      Location:253
      Prothymosin; Prothymosin/parathymosin family
    2. NM_001360831.1NP_001347760.1  prothymosin alpha isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC158132
      Conserved Domains (1) summary
      pfam03247
      Location:247
      Prothymosin; Prothymosin/parathymosin family
    3. NM_008972.3NP_032998.1  prothymosin alpha isoform 1

      See identical proteins and their annotated locations for NP_032998.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC158132, AK132003, CN717467
      Consensus CDS
      CCDS35649.1
      UniProtKB/Swiss-Prot
      P26350
      UniProtKB/TrEMBL
      Q0VGU2
      Related
      ENSMUSP00000044188.9, ENSMUST00000045897.15
      Conserved Domains (1) summary
      pfam03247
      Location:2110
      Prothymosin; Prothymosin/parathymosin family

    RNA

    1. NR_153833.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC158132
    2. NR_153834.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria
      Source sequence(s)
      AC158132

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86454279..86458434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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