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    Twf1 twinfilin actin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19230, updated on 9-Sep-2018

    Summary

    Official Symbol
    Twf1provided by MGI
    Official Full Name
    twinfilin actin binding protein 1provided by MGI
    Primary source
    MGI:MGI:1100520
    See related
    Ensembl:ENSMUSG00000022451 Vega:OTTMUSG00000017538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A6; Ptk9; twinfilin
    Expression
    Ubiquitous expression in bladder adult (RPKM 32.3), large intestine adult (RPKM 27.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Twf1 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (94577948..94589884, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (94408379..94420255, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene pseudouridylate synthase 7-like Neighboring gene interleukin-1 receptor-associated kinase 4 Neighboring gene predicted gene, 30754 Neighboring gene transmembrane protein 117 Neighboring gene predicted gene, 31007

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin monomer binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle hypertrophy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of actin phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequestering of actin monomers IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    twinfilin-1
    Names
    PTK9 protein tyrosine kinase 9
    actin monomer-binding protein
    protein A6
    protein tyrosine kinase 9
    twinfilin, actin-binding protein, homolog 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008971.4NP_032997.3  twinfilin-1

      See identical proteins and their annotated locations for NP_032997.3

      Status: PROVISIONAL

      Source sequence(s)
      AC147160
      Consensus CDS
      CCDS27773.1
      UniProtKB/Swiss-Prot
      Q91YR1
      Related
      ENSMUSP00000023087.6, OTTMUSP00000019148, ENSMUST00000023087.12, OTTMUST00000042612
      Conserved Domains (2) summary
      cd11284
      Location:176311
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:4142
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      94577948..94589884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520638.1XP_006520701.1  twinfilin-1 isoform X1

      Conserved Domains (2) summary
      cd11284
      Location:150285
      ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
      cd11285
      Location:9116
      ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins
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