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    Nadk NAD kinase [ Mus musculus (house mouse) ]

    Gene ID: 192185, updated on 31-Jan-2019

    Summary

    Official Symbol
    Nadkprovided by MGI
    Official Full Name
    NAD kinaseprovided by MGI
    Primary source
    MGI:MGI:2183149
    See related
    Ensembl:ENSMUSG00000029063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC004012; 4432404C02Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 138.3), liver adult (RPKM 72.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nadk in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (155562392..155591001)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154936501..154965110)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52 Neighboring gene guanine nucleotide binding protein (G protein), beta 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin-dependent kinase 11B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Pathways from BioSystems

    General gene information

    Homology

    Clone Names

    • MGC7589

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NAD+ kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    NADP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD kinase
    Names
    Putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase)
    poly(P)/ATP NAD kinase
    NP_001153109.1
    NP_619612.2
    XP_006538725.1
    XP_006538726.1
    XP_006538727.1
    XP_006538728.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159637.1NP_001153109.1  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_001153109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA197692, AK147917, AW455445, BE950056, BF453238, BF682935, CJ166231
      Consensus CDS
      CCDS19031.1
      UniProtKB/Swiss-Prot
      P58058
      UniProtKB/TrEMBL
      Q3UGI1
      Related
      ENSMUSP00000101238.3, ENSMUST00000105613.9
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. NM_001355599.1NP_001342528.1  NAD kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK147917, BB869695, BE950056, BP767626, BY202795, CF916286, CK334104, DV043414
      Conserved Domains (1) summary
      cl28462
      Location:9342
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
    3. NM_138671.3NP_619612.2  NAD kinase isoform 1

      See identical proteins and their annotated locations for NP_619612.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK147917, BE950056, BP767626, BY154310, CF916286, CK334104, DV043414
      Consensus CDS
      CCDS19031.1
      UniProtKB/Swiss-Prot
      P58058
      Related
      ENSMUSP00000030939.7, ENSMUST00000030939.13
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      155562392..155591001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538665.3XP_006538728.1  NAD kinase isoform X3

      Conserved Domains (1) summary
      cl01255
      Location:98310
      DAGK_cat; Diacylglycerol kinase catalytic domain
    2. XM_006538662.3XP_006538725.1  NAD kinase isoform X1

      See identical proteins and their annotated locations for XP_006538725.1

      UniProtKB/Swiss-Prot
      P58058
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain
    3. XM_006538663.3XP_006538726.1  NAD kinase isoform X1

      See identical proteins and their annotated locations for XP_006538726.1

      UniProtKB/Swiss-Prot
      P58058
      Conserved Domains (1) summary
      cl01255
      Location:98429
      DAGK_cat; Diacylglycerol kinase catalytic domain
    4. XM_006538664.3XP_006538727.1  NAD kinase isoform X2

      Related
      ENSMUSP00000101237.1, ENSMUST00000105612.1
      Conserved Domains (1) summary
      cl28462
      Location:9342
      pnk; inorganic polyphosphate/ATP-NAD kinase; Provisional
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