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    Eif4a3 eukaryotic translation initiation factor 4A3 [ Mus musculus (house mouse) ]

    Gene ID: 192170, updated on 3-Feb-2019

    Summary

    Official Symbol
    Eif4a3provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A3provided by MGI
    Primary source
    MGI:MGI:1923731
    See related
    Ensembl:ENSMUSG00000025580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx48; eIF4A-III; mKIAA0111; 2400003O03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 64.0), limb E14.5 (RPKM 53.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Eif4a3 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (119288363..119300043, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (119149677..119161357, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene glucosidase, alpha, acid Neighboring gene predicted gene, 39483 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene solute carrier family 26, member 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6664, MGC6715

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATP-dependent RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-III
    Names
    ATP-dependent RNA helicase DDX48
    ATP-dependent RNA helicase eIF4A-3
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
    DEAD box protein 48
    eIF-4A-III
    eukaryotic translation initiation factor 4A, isoform 3
    NP_619610.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138669.1NP_619610.1  eukaryotic initiation factor 4A-III

      See identical proteins and their annotated locations for NP_619610.1

      Status: PROVISIONAL

      Source sequence(s)
      BC008132
      Consensus CDS
      CCDS25714.1
      UniProtKB/Swiss-Prot
      Q91VC3
      Related
      ENSMUSP00000026667.8, ENSMUST00000026667.14
      Conserved Domains (3) summary
      PTZ00424
      Location:35411
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:251380
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:40240
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      119288363..119300043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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