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    Eif4a3 eukaryotic translation initiation factor 4A3 [ Mus musculus (house mouse) ]

    Gene ID: 192170, updated on 22-Aug-2021

    Summary

    Official Symbol
    Eif4a3provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4A3provided by MGI
    Primary source
    MGI:MGI:1923731
    See related
    Ensembl:ENSMUSG00000025580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx48; eIF4A-III; mKIAA0111; 2400003O03Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 64.0), limb E14.5 (RPKM 53.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif4a3 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119179189..119190869, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119288363..119300043, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (119149677..119161357, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 40 Neighboring gene predicted gene, 46303 Neighboring gene glucosidase, alpha, acid Neighboring gene predicted gene, 39483 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene N-sulfoglucosamine sulfohydrolase (sulfamidase) Neighboring gene solute carrier family 26, member 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6664, MGC6715

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exon-exon junction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic initiation factor 4A-III
    Names
    ATP-dependent RNA helicase DDX48
    ATP-dependent RNA helicase eIF4A-3
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 48
    DEAD box protein 48
    eIF-4A-III
    NP_619610.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138669.1NP_619610.1  eukaryotic initiation factor 4A-III

      See identical proteins and their annotated locations for NP_619610.1

      Status: PROVISIONAL

      Source sequence(s)
      BC008132
      Consensus CDS
      CCDS25714.1
      UniProtKB/Swiss-Prot
      Q91VC3
      Related
      ENSMUSP00000026667.9, ENSMUST00000026667.15
      Conserved Domains (3) summary
      PTZ00424
      Location:35411
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:251380
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:40240
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119179189..119190869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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