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    Dicer1 dicer 1, ribonuclease type III [ Mus musculus (house mouse) ]

    Gene ID: 192119, updated on 14-Sep-2021

    Summary

    Official Symbol
    Dicer1provided by MGI
    Official Full Name
    dicer 1, ribonuclease type IIIprovided by MGI
    Primary source
    MGI:MGI:2177178
    See related
    Ensembl:ENSMUSG00000041415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dice; aviD; D12Ertd7; D12Ertd7e; mKIAA0928; 1110006F08Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), CNS E14 (RPKM 8.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dicer1 in Genome Data Viewer
    Location:
    12 E; 12 54.83 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104653999..104718227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104687740..104751968, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (105925952..105990162, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53760 Neighboring gene predicted gene, 31573 Neighboring gene calmin Neighboring gene predicted gene, 53761 Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene predicted gene, 31742

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables endoribonuclease activity, producing 5'-phosphomonoesters IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribonuclease III activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease III activity TAS
    Traceable Author Statement
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in RNA phosphodiester bond hydrolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in RNA phosphodiester bond hydrolysis, endonucleolytic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in conversion of ds siRNA to ss siRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in conversion of ds siRNA to ss siRNA involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory bulb interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pericentric heterochromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in production of siRNA involved in RNA interference IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within production of siRNA involved in RNA interference IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in production of siRNA involved in RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in production of siRNA involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Notch signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in siRNA loading onto RISC involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in targeting of mRNA for destruction involved in RNA interference ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within trophectodermal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within zygote asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    double-strand-specific ribonuclease mDCR-1
    NP_683750.2
    XP_006515671.1
    XP_006515672.1
    XP_006515674.1
    XP_017170486.1
    XP_017170487.1
    XP_017170488.1
    XP_036013153.1
    XP_036013154.1
    XP_036013155.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148948.2NP_683750.2  endoribonuclease Dicer

      See identical proteins and their annotated locations for NP_683750.2

      Status: VALIDATED

      Source sequence(s)
      AC124364
      Consensus CDS
      CCDS36539.1
      UniProtKB/TrEMBL
      F8VQ54
      Related
      ENSMUSP00000043676.7, ENSMUST00000041987.7
      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104653999..104718227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314997.2XP_017170486.1  endoribonuclease Dicer isoform X4

      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      cd00593
      Location:16661751
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain
    2. XM_017314999.3XP_017170488.1  endoribonuclease Dicer isoform X6

      Conserved Domains (5) summary
      smart00535
      Location:803894
      RIBOc; Ribonuclease III family
      COG0571
      Location:11671419
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:393515
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cl38915
      Location:171
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam03368
      Location:137225
      Dicer_dimer; Dicer dimerization domain
    3. XM_006515611.4XP_006515674.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_006515674.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain
    4. XM_036157262.1XP_036013155.1  endoribonuclease Dicer isoform X3

      Conserved Domains (7) summary
      COG0571
      Location:15981850
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00593
      Location:12861348
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain
    5. XM_006515608.4XP_006515671.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_006515671.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain
    6. XM_036157260.1XP_036013153.1  endoribonuclease Dicer isoform X2

      Conserved Domains (7) summary
      smart00535
      Location:12661357
      RIBOc; Ribonuclease III family
      COG0571
      Location:16301882
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:856978
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:241335
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:342534
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:19209
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:600688
      Dicer_dimer; Dicer dimerization domain
    7. XM_017314998.3XP_017170487.1  endoribonuclease Dicer isoform X5

      Conserved Domains (7) summary
      smart00535
      Location:11471238
      RIBOc; Ribonuclease III family
      COG0571
      Location:15111763
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:737859
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:122216
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:223415
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:481569
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:190
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    8. XM_036157261.1XP_036013154.1  endoribonuclease Dicer isoform X2

      Conserved Domains (7) summary
      smart00535
      Location:12661357
      RIBOc; Ribonuclease III family
      COG0571
      Location:16301882
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:856978
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:241335
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:342534
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:19209
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:600688
      Dicer_dimer; Dicer dimerization domain
    9. XM_006515609.4XP_006515672.1  endoribonuclease Dicer isoform X1

      See identical proteins and their annotated locations for XP_006515672.1

      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain
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