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    Dicer1 dicer 1, ribonuclease type III [ Mus musculus (house mouse) ]

    Gene ID: 192119, updated on 3-Dec-2024

    Summary

    Official Symbol
    Dicer1provided by MGI
    Official Full Name
    dicer 1, ribonuclease type IIIprovided by MGI
    Primary source
    MGI:MGI:2177178
    See related
    Ensembl:ENSMUSG00000041415 AllianceGenome:MGI:2177178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    aviD; D12Ertd7e; mKIAA0928; 1110006F08Rik
    Summary
    Enables miRNA binding activity. Involved in several processes, including nervous system development; regulation of gene expression; and regulation of nervous system development. Acts upstream of or within several processes, including circulatory system development; nervous system development; and regulation of gene expression. Located in cytoplasm. Part of RISC complex and RISC-loading complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study DiGeorge syndrome; dilated cardiomyopathy; and ovarian cancer. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.4), CNS E14 (RPKM 8.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dicer1 in Genome Data Viewer
    Location:
    12 E; 12 54.83 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104654001..104718331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104687740..104751968, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53760 Neighboring gene predicted gene, 31573 Neighboring gene STARR-positive B cell enhancer ABC_E7176 Neighboring gene STARR-seq mESC enhancer starr_33151 Neighboring gene calmin Neighboring gene predicted gene, 53761 Neighboring gene STARR-seq mESC enhancer starr_33155 Neighboring gene spectrin repeat containing, nuclear envelope family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1453 Neighboring gene STARR-seq mESC enhancer starr_33158 Neighboring gene predicted gene, 31742

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pre-miRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonuclease III activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonuclease III activity TAS
    Traceable Author Statement
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RISC complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within RNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within RNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ganglion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in global gene silencing by mRNA cleavage ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in global gene silencing by mRNA cleavage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within inner ear receptor cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within myoblast differentiation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of Schwann cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within olfactory bulb interneuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system myelin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Schwann cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hepatic stellate cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pre-miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of Notch signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within regulation of RNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of miRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within reproductive structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within siRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in siRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in siRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within trophectodermal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within zygote asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RISC-loading complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    double-strand-specific ribonuclease mDCR-1
    NP_001398758.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411829.1NP_001398758.1  endoribonuclease Dicer isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124364, AF430845
      UniProtKB/TrEMBL
      F8VQ54
      Related
      ENSMUSP00000043676.8, ENSMUST00000041987.8
    2. NM_148948.2NP_683750.2  endoribonuclease Dicer isoform 2

      See identical proteins and their annotated locations for NP_683750.2

      Status: VALIDATED

      Source sequence(s)
      AC124364
      UniProtKB/TrEMBL
      F8VQ54
      Conserved Domains (7) summary
      smart00535
      Location:12861377
      RIBOc; Ribonuclease III family
      COG0571
      Location:16501902
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:876998
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:261355
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:362554
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:32229
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:620708
      Dicer_dimer; Dicer dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104654001..104718331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)