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    Ptbp1 polypyrimidine tract binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 19205, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ptbp1provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 1provided by MGI
    Primary source
    MGI:MGI:97791
    See related
    Ensembl:ENSMUSG00000006498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pt; Ptb; PTB2; PTB3; PTB4; pPTB; HNRPI; PTB-1; D12Mgi4; AA407203; AL033359
    Expression
    Ubiquitous expression in thymus adult (RPKM 115.0), limb E14.5 (RPKM 113.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ptbp1 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79690266..79700269)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79854432..79864435)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79317350..79327178)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40713 Neighboring gene paralemmin Neighboring gene mitotic spindle positioning Neighboring gene RIKEN cDNA E130317F20 gene Neighboring gene phospholipid phosphatase related 3 Neighboring gene microRNA 6910 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_negative_effect gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polypyrimidine tract-binding protein 1
    Names
    heterogeneous nuclear ribonucleoprotein I
    hnRNP I

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077363.2NP_001070831.1  polypyrimidine tract-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001070831.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK151292, CA977830, CJ075278
      Consensus CDS
      CCDS35969.1
      UniProtKB/TrEMBL
      Q922I7
      Related
      ENSMUSP00000126192.2, ENSMUST00000172282.8
      Conserved Domains (1) summary
      TIGR01649
      Location:56555
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. NM_001283013.1NP_001269942.1  polypyrimidine tract-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001269942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate segment and an exon in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks two internal segments, compared to isoform 1.
      Source sequence(s)
      AK036745, CA977830, CJ075278
      Consensus CDS
      CCDS70064.1
      UniProtKB/TrEMBL
      Q8CB58
      Related
      ENSMUSP00000093109.5, ENSMUST00000095457.11
      Conserved Domains (3) summary
      cd12693
      Location:140235
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      TIGR01649
      Location:36489
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
      cl17169
      Location:296388
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_008956.3NP_032982.2  polypyrimidine tract-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_032982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK082600, AK151292, CA977830, CJ075278
      Consensus CDS
      CCDS35970.1
      UniProtKB/TrEMBL
      Q8BGJ5, Q922I7
      Related
      ENSMUSP00000127783.2, ENSMUST00000165704.8
      Conserved Domains (1) summary
      TIGR01649
      Location:56529
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79690266..79700269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003948623.2 RNA Sequence

    2. XR_003948622.2 RNA Sequence

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