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    Cyth3 cytohesin 3 [ Mus musculus (house mouse) ]

    Gene ID: 19159, updated on 16-Oct-2021

    Summary

    Official Symbol
    Cyth3provided by MGI
    Official Full Name
    cytohesin 3provided by MGI
    Primary source
    MGI:MGI:1335107
    See related
    Ensembl:ENSMUSG00000018001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLM3; Grp1; ARNO3; Pscd3; AI648983
    Expression
    Ubiquitous expression in lung adult (RPKM 52.5), adrenal adult (RPKM 28.2) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cyth3 in Genome Data Viewer
    Location:
    5 G2; 5 82.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143608202..143696005)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143622447..143710250)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144383316..144471119)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 220, member A Neighboring gene predicted gene, 54311 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene predicted gene, 38737 Neighboring gene RIKEN cDNA D130017N08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4241

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    cytohesin-3
    Names
    ARF nucleotide-binding site opener 3
    PH, SEC7 and coiled-coil domain-containing protein 3
    SEC7 homolog C
    general receptor of phosphoinositides 1
    mSec7-3
    pleckstrin homology, Sec7 and coiled-coil domains 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163548.1NP_001157020.1  cytohesin-3 isoform 2

      See identical proteins and their annotated locations for NP_001157020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI846077, AK016645, AK159229
      Consensus CDS
      CCDS51691.1
      UniProtKB/TrEMBL
      G5E8Q4, Q3TXK1
      Related
      ENSMUSP00000106355.2, ENSMUST00000110727.2
      Conserved Domains (2) summary
      cd01252
      Location:215334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18200
      Sec7; Sec7 domain
    2. NM_011182.4NP_035312.3  cytohesin-3 isoform 1

      See identical proteins and their annotated locations for NP_035312.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI846077, AK159229, BY271755
      Consensus CDS
      CCDS19845.1
      UniProtKB/Swiss-Prot
      O08967
      UniProtKB/TrEMBL
      Q3TXK1
      Related
      ENSMUSP00000112157.4, ENSMUST00000116456.10
      Conserved Domains (2) summary
      cd01252
      Location:263382
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:66248
      Sec7; Sec7 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143608202..143696005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164909.1XP_036020802.1  cytohesin-3 isoform X1

      Conserved Domains (2) summary
      cd01252
      Location:236355
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:66221
      Sec7; Sec7 domain
    2. XM_017320729.3XP_017176218.1  cytohesin-3 isoform X2

      UniProtKB/TrEMBL
      G5E8Q4
      Conserved Domains (2) summary
      cd01252
      Location:215334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18200
      Sec7; Sec7 domain
    3. XM_030254209.1XP_030110069.1  cytohesin-3 isoform X2

      Conserved Domains (2) summary
      cd01252
      Location:215334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18200
      Sec7; Sec7 domain
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