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    Cyth3 cytohesin 3 [ Mus musculus (house mouse) ]

    Gene ID: 19159, updated on 28-Aug-2018

    Summary

    Official Symbol
    Cyth3provided by MGI
    Official Full Name
    cytohesin 3provided by MGI
    Primary source
    MGI:MGI:1335107
    See related
    Ensembl:ENSMUSG00000018001 Vega:OTTMUSG00000023404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLM3; Grp1; ARNO3; Pscd3; AI648983
    Expression
    Ubiquitous expression in lung adult (RPKM 52.5), adrenal adult (RPKM 28.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Cyth3 in Genome Data Viewer
    Location:
    5 G2; 5 82.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (143622447..143710250)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144383316..144471119)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene Rac family small GTPase 1 Neighboring gene family with sequence similarity 220, member A Neighboring gene ubiquitin specific peptidase 42 Neighboring gene predicted gene, 38737 Neighboring gene RIKEN cDNA D130017N08 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4241

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ARF guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi vesicle transport ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of epithelial cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    cytohesin-3
    Names
    ARF nucleotide-binding site opener 3
    PH, SEC7 and coiled-coil domain-containing protein 3
    SEC7 homolog C
    general receptor of phosphoinositides 1
    mSec7-3
    pleckstrin homology, Sec7 and coiled-coil domains 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163548.1NP_001157020.1  cytohesin-3 isoform 2

      See identical proteins and their annotated locations for NP_001157020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI846077, AK016645, AK159229
      Consensus CDS
      CCDS51691.1
      UniProtKB/TrEMBL
      G5E8Q4, Q3TXK1
      Related
      ENSMUSP00000106355.1, OTTMUSP00000027370, ENSMUST00000110727.1, OTTMUST00000056847
      Conserved Domains (2) summary
      cd01252
      Location:215334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18200
      Sec7; Sec7 domain
    2. NM_011182.4NP_035312.3  cytohesin-3 isoform 1

      See identical proteins and their annotated locations for NP_035312.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI846077, AK159229, BY271755
      Consensus CDS
      CCDS19845.1
      UniProtKB/Swiss-Prot
      O08967
      UniProtKB/TrEMBL
      Q3TXK1
      Related
      ENSMUSP00000112157.3, OTTMUSP00000027369, ENSMUST00000116456.9, OTTMUST00000056846
      Conserved Domains (2) summary
      cd01252
      Location:263382
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:66248
      Sec7; Sec7 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      143622447..143710250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320729.1XP_017176218.1  cytohesin-3 isoform X1

      UniProtKB/TrEMBL
      G5E8Q4
      Conserved Domains (2) summary
      cd01252
      Location:215334
      PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
      pfam01369
      Location:18200
      Sec7; Sec7 domain
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