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    Helq helicase, POLQ-like [ Mus musculus (house mouse) ]

    Gene ID: 191578, updated on 26-Sep-2022

    Summary

    Official Symbol
    Helqprovided by MGI
    Official Full Name
    helicase, POLQ-likeprovided by MGI
    Primary source
    MGI:MGI:2176740
    See related
    Ensembl:ENSMUSG00000035266 AllianceGenome:MGI:2176740
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hel308; D430018E21Rik
    Summary
    Predicted to enable single-stranded 3'-5' DNA helicase activity. Predicted to be involved in double-strand break repair via homologous recombination and rRNA processing. Predicted to act upstream of or within DNA metabolic process. Predicted to be part of single-stranded DNA-dependent ATP-dependent DNA helicase complex. Predicted to be active in nucleus. Orthologous to human HELQ (helicase, POLQ like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.7), CNS E14 (RPKM 3.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Helq in Genome Data Viewer
    Location:
    5; 5 E4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100910010..100946529, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (100762144..100798661, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene heparanase Neighboring gene predicted gene, 36619 Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene BRCA1 A complex subunit Neighboring gene predicted gene, 26286

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105224

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of single-stranded DNA-dependent ATP-dependent DNA helicase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    helicase POLQ-like
    Names
    DNA helicase Hel308
    POLQ-like helicase
    helicase, mus308-like
    mus308-like helicase
    NP_001074576.1
    XP_006534885.1
    XP_006534886.1
    XP_006534889.1
    XP_006534890.1
    XP_006534892.1
    XP_017176216.1
    XP_017176217.1
    XP_030110068.1
    XP_036020800.1
    XP_036020801.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081107.1NP_001074576.1  helicase POLQ-like

      See identical proteins and their annotated locations for NP_001074576.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161510
      Consensus CDS
      CCDS39184.1
      UniProtKB/Swiss-Prot
      Q2VPA6, Q8R4K9
      Related
      ENSMUSP00000041599.8, ENSMUST00000044684.14
      Conserved Domains (4) summary
      smart00490
      Location:597671
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:2771024
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:304465
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:9711024
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      100910010..100946529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534829.3XP_006534892.1  helicase POLQ-like isoform X9

      Conserved Domains (1) summary
      PRK02362
      Location:20521
      PRK02362; ATP-dependent DNA helicase
    2. XM_036164908.1XP_036020801.1  helicase POLQ-like isoform X10

      Conserved Domains (1) summary
      PRK02362
      Location:3504
      PRK02362; ATP-dependent DNA helicase
    3. XM_006534823.4XP_006534886.1  helicase POLQ-like isoform X2

      Conserved Domains (3) summary
      PHA03307
      Location:35327
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK02362
      Location:3491063
      PRK02362; ATP-dependent DNA helicase
      cd18026
      Location:350552
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
    4. XM_017320728.2XP_017176217.1  helicase POLQ-like isoform X4

      Conserved Domains (3) summary
      PHA03307
      Location:35327
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK02362
      Location:3491005
      PRK02362; ATP-dependent DNA helicase
      cd18026
      Location:350552
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
    5. XM_017320727.2XP_017176216.1  helicase POLQ-like isoform X3

      Related
      ENSMUSP00000116470.2, ENSMUST00000133845.8
      Conserved Domains (3) summary
      PHA03307
      Location:35327
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK02362
      Location:349847
      PRK02362; ATP-dependent DNA helicase
      cd18026
      Location:350552
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
    6. XM_006534822.4XP_006534885.1  helicase POLQ-like isoform X1

      Conserved Domains (3) summary
      PHA03307
      Location:35327
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK02362
      Location:3491096
      PRK02362; ATP-dependent DNA helicase
      cd18026
      Location:350552
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta
    7. XM_030254208.1XP_030110068.1  helicase POLQ-like isoform X7

      Conserved Domains (1) summary
      PRK02362
      Location:39669
      PRK02362; ATP-dependent DNA helicase
    8. XM_036164907.1XP_036020800.1  helicase POLQ-like isoform X8

      Conserved Domains (1) summary
      PRK02362
      Location:1599
      PRK02362; ATP-dependent DNA helicase
    9. XM_006534827.5XP_006534890.1  helicase POLQ-like isoform X6

      Conserved Domains (1) summary
      PRK02362
      Location:13693
      PRK02362; ATP-dependent DNA helicase
    10. XM_006534826.4XP_006534889.1  helicase POLQ-like isoform X5

      Conserved Domains (3) summary
      PHA03307
      Location:35327
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1204
      Location:340804
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18026
      Location:350552
      DEXHc_POLQ-like; DEXH-box helicase domain of DNA polymerase theta

    RNA

    1. XR_004942457.1 RNA Sequence

    2. XR_001784644.3 RNA Sequence

    3. XR_004942458.1 RNA Sequence

    4. XR_004942459.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180984.2: Suppressed sequence

      Description
      NM_180984.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.