Format

Send to:

Choose Destination
    • Showing Current items.

    Helq helicase, POLQ-like [ Mus musculus (house mouse) ]

    Gene ID: 191578, updated on 5-Aug-2018

    Summary

    Official Symbol
    Helqprovided by MGI
    Official Full Name
    helicase, POLQ-likeprovided by MGI
    Primary source
    MGI:MGI:2176740
    See related
    Ensembl:ENSMUSG00000035266 Vega:OTTMUSG00000026173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hel308; AU021725; D430018E21Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.7), CNS E14 (RPKM 3.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Helq in Genome Data Viewer
    Location:
    5; 5 E4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (100762144..100798663, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (101191167..101227619, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene heparanase Neighboring gene predicted gene, 36619 Neighboring gene mitochondrial ribosomal protein S18C Neighboring gene BRCA1 A complex subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105224

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA-dependent ATP-dependent DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    single-stranded DNA-dependent ATP-dependent DNA helicase complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    helicase POLQ-like
    Names
    DNA helicase Hel308
    POLQ-like helicase
    helicase, mus308-like
    mus308-like helicase
    NP_001074576.1
    XP_006534885.1
    XP_006534886.1
    XP_006534889.1
    XP_006534890.1
    XP_006534891.1
    XP_006534892.1
    XP_017176216.1
    XP_017176217.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081107.1NP_001074576.1  helicase POLQ-like

      See identical proteins and their annotated locations for NP_001074576.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161510
      Consensus CDS
      CCDS39184.1
      UniProtKB/Swiss-Prot
      Q2VPA6
      Related
      ENSMUSP00000041599.7, OTTMUSP00000032142, ENSMUST00000044684.13, OTTMUST00000064661
      Conserved Domains (4) summary
      smart00490
      Location:597671
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:2771024
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:304465
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:9711024
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      100762144..100798663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534828.2XP_006534891.1  helicase POLQ-like isoform X7

      Conserved Domains (4) summary
      smart00490
      Location:242316
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:39669
      PRK02362; ski2-like helicase; Provisional
      pfam14520
      Location:616669
      HHH_5; Helix-hairpin-helix domain
      cl21455
      Location:1110
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006534827.3XP_006534890.1  helicase POLQ-like isoform X6

      Conserved Domains (4) summary
      PRK01172
      Location:4699
      PRK01172; ski2-like helicase; Provisional
      smart00490
      Location:266340
      HELICc; helicase superfamily c-terminal domain
      pfam00270
      Location:1134
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:640693
      HHH_5; Helix-hairpin-helix domain
    3. XM_006534829.2XP_006534892.1  helicase POLQ-like isoform X8

      Conserved Domains (3) summary
      smart00490
      Location:94168
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:20521
      PRK02362; ski2-like helicase; Provisional
      pfam14520
      Location:468521
      HHH_5; Helix-hairpin-helix domain
    4. XM_006534823.3XP_006534886.1  helicase POLQ-like isoform X2

      Conserved Domains (4) summary
      smart00490
      Location:636710
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:3491063
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:376537
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:10101063
      HHH_5; Helix-hairpin-helix domain
    5. XM_017320728.1XP_017176217.1  helicase POLQ-like isoform X4

    6. XM_017320727.1XP_017176216.1  helicase POLQ-like isoform X3

      Related
      ENSMUSP00000116470.1, OTTMUSP00000032163, ENSMUST00000133845.7, OTTMUST00000064696
    7. XM_006534822.3XP_006534885.1  helicase POLQ-like isoform X1

      Conserved Domains (4) summary
      smart00490
      Location:669743
      HELICc; helicase superfamily c-terminal domain
      PRK02362
      Location:3491096
      PRK02362; ski2-like helicase; Provisional
      pfam00270
      Location:376537
      DEAD; DEAD/DEAH box helicase
      pfam14520
      Location:10431096
      HHH_5; Helix-hairpin-helix domain
    8. XM_006534826.2XP_006534889.1  helicase POLQ-like isoform X5

      Conserved Domains (3) summary
      smart00490
      Location:669743
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:359558
      DEXDc; DEAD-like helicases superfamily
      pfam00270
      Location:376537
      DEAD; DEAD/DEAH box helicase

    RNA

    1. XR_001784644.1 RNA Sequence

      Related
      ENSMUST00000151201.1, OTTMUST00000064695

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_180984.2: Suppressed sequence

      Description
      NM_180984.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Support Center