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    Prpf4b pre-mRNA processing factor 4B [ Mus musculus (house mouse) ]

    Gene ID: 19134, updated on 12-Aug-2018

    Summary

    Official Symbol
    Prpf4bprovided by MGI
    Official Full Name
    pre-mRNA processing factor 4Bprovided by MGI
    Primary source
    MGI:MGI:109584
    See related
    Ensembl:ENSMUSG00000021413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prp4; Prpk; Prp4k; cbp143; 2610037H07
    Expression
    Broad expression in CNS E11.5 (RPKM 19.1), limb E14.5 (RPKM 16.8) and 22 other tissues See more
    Orthologs

    Genomic context

    See Prpf4b in Genome Data Viewer
    Location:
    13; 13 A3.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (34875294..34906064)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (34967363..34994747)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene predicted gene, 36839 Neighboring gene RIKEN cDNA 4933417A18 gene Neighboring gene family with sequence similarity 217, member A Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC5960

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase PRP4 homolog
    Names
    PRP4 pre-mRNA processing factor 4 homolog B
    PRP4 pre-mRNA-processing factor 4 homolog
    pre-mRNA protein kinase
    NP_038858.2
    XP_006516645.1
    XP_006516646.1
    XP_006516647.1
    XP_017170914.1
    XP_017170915.1
    XP_017170916.1
    XP_017170917.1
    XP_017170918.1
    XP_017170919.1
    XP_017170920.1
    XP_017170921.1
    XP_017170922.1
    XP_017170923.1
    XP_017170924.1
    XP_017170925.1
    XP_017170926.1
    XP_017170927.1
    XP_017170928.1
    XP_017170929.1
    XP_017170930.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013830.2NP_038858.2  serine/threonine-protein kinase PRP4 homolog

      See identical proteins and their annotated locations for NP_038858.2

      Status: VALIDATED

      Source sequence(s)
      AF283466, AK078611, BE985603, CJ046150
      Consensus CDS
      CCDS26448.1
      UniProtKB/Swiss-Prot
      Q61136
      UniProtKB/TrEMBL
      Q8C5G1
      Related
      ENSMUSP00000077019.3, ENSMUST00000077853.4
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      34875294..34906064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315441.1XP_017170930.1  serine/threonine-protein kinase PRP4 homolog isoform X6

      Conserved Domains (1) summary
      PTZ00108
      Location:171396
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
    2. XM_017315440.1XP_017170929.1  serine/threonine-protein kinase PRP4 homolog isoform X5

    3. XM_017315439.1XP_017170928.1  serine/threonine-protein kinase PRP4 homolog isoform X5

    4. XM_017315427.1XP_017170916.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    5. XM_017315432.1XP_017170921.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    6. XM_017315435.1XP_017170924.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    7. XM_017315436.1XP_017170925.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    8. XM_017315437.1XP_017170926.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    9. XM_017315438.1XP_017170927.1  serine/threonine-protein kinase PRP4 homolog isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:694860
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
      cl21453
      Location:686860
      PKc_like; Protein Kinases, catalytic domain
    10. XM_006516583.3XP_006516646.1  serine/threonine-protein kinase PRP4 homolog isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:694860
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
      cl21453
      Location:686860
      PKc_like; Protein Kinases, catalytic domain
    11. XM_006516584.3XP_006516647.1  serine/threonine-protein kinase PRP4 homolog isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:694860
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
      cl21453
      Location:686860
      PKc_like; Protein Kinases, catalytic domain
    12. XM_006516582.3XP_006516645.1  serine/threonine-protein kinase PRP4 homolog isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:694860
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
      cl21453
      Location:686860
      PKc_like; Protein Kinases, catalytic domain
    13. XM_017315426.1XP_017170915.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    14. XM_017315428.1XP_017170917.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    15. XM_017315433.1XP_017170922.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    16. XM_017315425.1XP_017170914.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    17. XM_017315431.1XP_017170920.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    18. XM_017315434.1XP_017170923.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    19. XM_017315429.1XP_017170918.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
    20. XM_017315430.1XP_017170919.1  serine/threonine-protein kinase PRP4 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q61136
      Conserved Domains (3) summary
      smart00220
      Location:6941003
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14135
      Location:6861003
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
      pfam10577
      Location:284388
      UPF0560; uncharacterized protein family UPF0560
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