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    Prkar2a protein kinase, cAMP dependent regulatory, type II alpha [ Mus musculus (house mouse) ]

    Gene ID: 19087, updated on 5-Sep-2021

    Summary

    Official Symbol
    Prkar2aprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type II alphaprovided by MGI
    Primary source
    MGI:MGI:108025
    See related
    Ensembl:ENSMUSG00000032601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RII; AI317181; AI836829; RII(alpha); 1110061A24Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 25.1), large intestine adult (RPKM 25.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Prkar2a in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108569342..108627643)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108692143..108750444)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108594474..108651843)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene predicted gene, 24259 Neighboring gene inositol hexaphosphate kinase 2 Neighboring gene predicted gene, 23034 Neighboring gene NCK interacting protein with SH3 domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cAMP-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type II-alpha regulatory subunit
    NP_032950.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008924.3NP_032950.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

      See identical proteins and their annotated locations for NP_032950.1

      Status: VALIDATED

      Source sequence(s)
      AC173341, CT571271
      Consensus CDS
      CCDS23536.1
      UniProtKB/TrEMBL
      Q8K1M3
      Related
      ENSMUSP00000035220.7, ENSMUST00000035220.12
      Conserved Domains (2) summary
      cd12103
      Location:444
      DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:259380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108569342..108627643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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