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    Prkar2a protein kinase, cAMP dependent regulatory, type II alpha [ Mus musculus (house mouse) ]

    Gene ID: 19087, updated on 9-Sep-2018

    Summary

    Official Symbol
    Prkar2aprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type II alphaprovided by MGI
    Primary source
    MGI:MGI:108025
    See related
    Ensembl:ENSMUSG00000032601 Vega:OTTMUSG00000050671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI317181; AI836829; RII(alpha); 1110061A24Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 25.1), large intestine adult (RPKM 25.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Prkar2a in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108692143..108749512)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108594474..108651843)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene ariadne RBR E3 ubiquitin protein ligase 2 Neighboring gene solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 Neighboring gene inositol hexaphosphate kinase 2 Neighboring gene NCK interacting protein with SH3 domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type II-alpha regulatory subunit
    NP_032950.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008924.2NP_032950.1  cAMP-dependent protein kinase type II-alpha regulatory subunit

      See identical proteins and their annotated locations for NP_032950.1

      Status: PROVISIONAL

      Source sequence(s)
      AC173341, CT571271
      Consensus CDS
      CCDS23536.1
      UniProtKB/TrEMBL
      Q8K1M3
      Related
      ENSMUSP00000035220.6, OTTMUSP00000069099, ENSMUST00000035220.11, OTTMUST00000128449
      Conserved Domains (3) summary
      cd12103
      Location:444
      DD_RIIalpha_PKA; Dimerization/Docking domain of the Type II alpha Regulatory subunit of cAMP-dependent protein kinase
      COG0664
      Location:253369
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:259380
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108692143..108749512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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