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    Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha [ Mus musculus (house mouse) ]

    Gene ID: 19084, updated on 6-Sep-2021

    Summary

    Official Symbol
    Prkar1aprovided by MGI
    Official Full Name
    protein kinase, cAMP dependent regulatory, type I, alphaprovided by MGI
    Primary source
    MGI:MGI:104878
    See related
    Ensembl:ENSMUSG00000020612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R; Tse; Tse-; Tse1; Tse-1; RIalpha; 1300018C22Rik
    Summary
    The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 81.7), cerebellum adult (RPKM 81.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prkar1a in Genome Data Viewer
    Location:
    11 E1; 11 72.33 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109539849..109560489)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109649023..109669663)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (109512263..109530962)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene predicted gene, 39442 Neighboring gene predicted gene 11685 Neighboring gene predicted gene, 39443 Neighboring gene FAM20A, golgi associated secretory pathway pseudokinase Neighboring gene uncharacterized LOC105243553 Neighboring gene predicted gene, 42093

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cAMP-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cAMP-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleotide-activated protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm connecting piece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type I-alpha regulatory subunit
    Names
    protein kinase, cAMP dependent regulatory, type 1, alpha
    NP_001300902.1
    NP_001300903.1
    NP_001300904.1
    NP_001300905.1
    NP_001349606.1
    NP_001360841.1
    NP_001360842.1
    NP_068680.1
    XP_036012323.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313973.2NP_001300902.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB610165, BP754173, BY309580
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Related
      ENSMUSP00000102288.2, ENSMUST00000106677.8
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001313974.2NP_001300903.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BP754173, BY129491
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001313975.2NP_001300904.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CX243222
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. NM_001313976.2NP_001300905.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK051068, AL732387, BB850806, BP754173, CF727817
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    5. NM_001362677.1NP_001349606.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Consensus CDS
      CCDS25583.1
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    6. NM_001373912.1NP_001360841.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK158562, AL732387
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    7. NM_001373913.1NP_001360842.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      Status: REVIEWED

      Source sequence(s)
      AK005039, AL732387
      Related
      ENSMUSP00000056500.7, ENSMUST00000049527.7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    8. NM_021880.4NP_068680.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

      See identical proteins and their annotated locations for NP_068680.1

      Status: REVIEWED

      Source sequence(s)
      AL732387, BP754173
      Consensus CDS
      CCDS25583.1
      UniProtKB/Swiss-Prot
      Q9DBC7
      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      109539849..109560489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156430.1XP_036012323.1  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1

      Conserved Domains (2) summary
      cd12101
      Location:1463
      DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
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