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    Prep prolyl endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 19072, updated on 23-Jun-2021

    Summary

    Official Symbol
    Prepprovided by MGI
    Official Full Name
    prolyl endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1270863
    See related
    Ensembl:ENSMUSG00000019849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PE; PEP; Pop; AI047692; AI450383; D10Wsu136; D10Wsu136e
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.1), placenta adult (RPKM 26.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prep in Genome Data Viewer
    Location:
    10 B2; 10 23.27 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44943312..45038847)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45067216..45162751)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (44787020..44878801)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40639 Neighboring gene RIKEN cDNA 2310075K07 gene Neighboring gene VISTA enhancer mm87 Neighboring gene predicted gene, 26016

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prolyl endopeptidase
    Names
    post-proline cleaving enzyme
    prolyl oligopeptidase
    NP_035286.1
    XP_011241444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011156.3NP_035286.1  prolyl endopeptidase

      See identical proteins and their annotated locations for NP_035286.1

      Status: VALIDATED

      Source sequence(s)
      AC153535, AK076257, AK163774, BP759584
      Consensus CDS
      CCDS23826.1
      UniProtKB/Swiss-Prot
      Q9QUR6
      UniProtKB/TrEMBL
      Q543B9
      Related
      ENSMUSP00000097444.3, ENSMUST00000099858.4
      Conserved Domains (2) summary
      COG1505
      Location:26704
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
      pfam00326
      Location:482707
      Peptidase_S9; Prolyl oligopeptidase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      44943312..45038847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243142.3XP_011241444.1  prolyl endopeptidase isoform X1

      Conserved Domains (1) summary
      COG1505
      Location:9477
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
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