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    Prep prolyl endopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 19072, updated on 5-Aug-2018

    Summary

    Official Symbol
    Prepprovided by MGI
    Official Full Name
    prolyl endopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1270863
    See related
    Ensembl:ENSMUSG00000019849 Vega:OTTMUSG00000063711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PE; PEP; Pop; AI047692; AI450383; D10Wsu136e
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.1), placenta adult (RPKM 26.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Prep in Genome Data Viewer
    Location:
    10 B2; 10 23.27 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (45067214..45159981)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (44787020..44878801)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 40639 Neighboring gene RIKEN cDNA 2310075K07 gene Neighboring gene predicted gene 15934 Neighboring gene popeye domain containing 3 Neighboring gene blood vessel epicardial substance

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from BioSystems

    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oligopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prolyl endopeptidase
    Names
    post-proline cleaving enzyme
    prolyl oligopeptidase
    NP_035286.1
    XP_011241444.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011156.3NP_035286.1  prolyl endopeptidase

      See identical proteins and their annotated locations for NP_035286.1

      Status: VALIDATED

      Source sequence(s)
      AC153535, AK076257, AK163774, BP759584
      Consensus CDS
      CCDS23826.1
      UniProtKB/Swiss-Prot
      Q9QUR6
      UniProtKB/TrEMBL
      Q543B9
      Related
      ENSMUSP00000097444.2, OTTMUSP00000080085, ENSMUST00000099858.3
      Conserved Domains (2) summary
      COG1505
      Location:26704
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
      pfam00326
      Location:482707
      Peptidase_S9; Prolyl oligopeptidase family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      45067214..45159981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243142.2XP_011241444.1  prolyl endopeptidase isoform X1

      Conserved Domains (2) summary
      COG1505
      Location:9477
      PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]
      pfam00326
      Location:255480
      Peptidase_S9; Prolyl oligopeptidase family
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