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    Nup88 nucleoporin 88 [ Mus musculus (house mouse) ]

    Gene ID: 19069, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nup88provided by MGI
    Official Full Name
    nucleoporin 88provided by MGI
    Primary source
    MGI:MGI:104900
    See related
    Ensembl:ENSMUSG00000040667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pr; Nup; Nup84; Prei2
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 33.6), CNS E14 (RPKM 26.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nup88 in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70833884..70860799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70943058..70969973, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70756573..70783475, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene ribosomal protein L23A, pseudogene 2 Neighboring gene predicted gene 12322 Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene predicted gene, 22297

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex protein Nup88
    Names
    88 kDa nucleoporin
    preimplantation protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083331.2NP_001076800.1  nuclear pore complex protein Nup88 isoform 2

      See identical proteins and their annotated locations for NP_001076800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AK028563, AK050893, AK160619
      Consensus CDS
      CCDS36206.1
      UniProtKB/Swiss-Prot
      Q8CEC0
      UniProtKB/TrEMBL
      Q5QNU0, Q8BQF0
      Related
      ENSMUSP00000048101.5, ENSMUST00000035283.11
      Conserved Domains (2) summary
      pfam10168
      Location:14751
      Nup88; Nuclear pore component
      pfam13863
      Location:570678
      DUF4200; Domain of unknown function (DUF4200)
    2. NM_001276406.1NP_001263335.1  nuclear pore complex protein Nup88 isoform 3

      See identical proteins and their annotated locations for NP_001263335.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, compared to variant 2. The encoded isoform (3) is shorter, compared to isoform 2.
      Source sequence(s)
      AK028563, AK050893, AK160619
      Consensus CDS
      CCDS70233.1
      UniProtKB/Swiss-Prot
      Q8CEC0
      UniProtKB/TrEMBL
      Q5QNU0, Q8BQF0
      Related
      ENSMUSP00000104171.2, ENSMUST00000108531.8
      Conserved Domains (2) summary
      pfam10168
      Location:14745
      Nup88; Nuclear pore component
      cl12013
      Location:589688
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_172394.3NP_765982.2  nuclear pore complex protein Nup88 isoform 1

      See identical proteins and their annotated locations for NP_765982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses two alternate splice sites in the coding region, compared to variant 2. The encoded isoform (1) is shorter, compared to isoform 2.
      Source sequence(s)
      AK050893, AK160619
      Consensus CDS
      CCDS36207.1
      UniProtKB/Swiss-Prot
      Q8CEC0
      UniProtKB/TrEMBL
      Q5QNU0, Q8BQF0
      Related
      ENSMUSP00000104170.2, ENSMUST00000108530.2
      Conserved Domains (2) summary
      pfam10168
      Location:14740
      Nup88; Nuclear pore component
      cl12013
      Location:584683
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_075087.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon structure, alternate splice sites in three internal exons, and lacks two internal exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK050893, AK139738, AK160619
      Related
      ENSMUST00000178253.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70833884..70860799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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