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    Ppp1ca protein phosphatase 1 catalytic subunit alpha [ Mus musculus (house mouse) ]

    Gene ID: 19045, updated on 5-Sep-2021

    Summary

    Official Symbol
    Ppp1caprovided by MGI
    Official Full Name
    protein phosphatase 1 catalytic subunit alphaprovided by MGI
    Primary source
    MGI:MGI:103016
    See related
    Ensembl:ENSMUSG00000040385
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp; dis; Ppp1c; dism2
    Expression
    Ubiquitous expression in thymus adult (RPKM 214.7), genital fat pad adult (RPKM 187.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ppp1ca in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4242173..4245418)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4192174..4195419)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4192174..4195419)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene carnosine synthase 1 Neighboring gene TBC1 domain family, member 10c Neighboring gene RAD9 checkpoint clamp component A Neighboring gene uncharacterized LOC102631992 Neighboring gene predicted gene, 30082 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cadherin binding involved in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in entrainment of circadian clock by photoperiod IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycogen metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein dephosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glycogen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to lead ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glycogen granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase type 1 complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Names
    PP-1A
    NP_114074.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031868.2NP_114074.1  serine/threonine-protein phosphatase PP1-alpha catalytic subunit

      See identical proteins and their annotated locations for NP_114074.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140073
      Consensus CDS
      CCDS29421.1
      UniProtKB/Swiss-Prot
      P62137
      Related
      ENSMUSP00000039109.5, ENSMUST00000046094.6
      Conserved Domains (2) summary
      PTZ00480
      Location:6308
      PTZ00480; serine/threonine-protein phosphatase; Provisional
      cd07414
      Location:8298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4242173..4245418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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