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    Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform [ Mus musculus (house mouse) ]

    Gene ID: 19043, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ppm1bprovided by MGI
    Official Full Name
    protein phosphatase 1B, magnesium dependent, beta isoformprovided by MGI
    Primary source
    MGI:MGI:101841
    See related
    Ensembl:ENSMUSG00000061130 AllianceGenome:MGI:101841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PP2CB
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in N-terminal protein myristoylation and protein dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including blastocyst; early embryo; gonad; liver; and lung. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 20.4), cerebellum adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppm1b in Genome Data Viewer
    Location:
    17 E4; 17 55.13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (85264169..85331420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84956741..85023992)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46582 Neighboring gene post-GPI attachment to proteins 2 pseudogene Neighboring gene RIKEN cDNA 1110020A21 gene Neighboring gene solute carrier family 3, member 1 Neighboring gene prolyl endopeptidase-like Neighboring gene calmodulin-lysine N-methyltransferase Neighboring gene predicted gene, 36826

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC106489

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cation binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein phosphatase 1B
    Names
    PP2C-beta
    NP_001152968.1
    NP_001152969.1
    NP_001152970.1
    NP_035281.1
    XP_006523923.1
    XP_006523924.1
    XP_006523925.1
    XP_011244623.1
    XP_011244624.1
    XP_030105452.1
    XP_030105453.1
    XP_030105454.1
    XP_036016306.1
    XP_036016307.1
    XP_036016308.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159496.2NP_001152968.1  protein phosphatase 1B isoform 1

      See identical proteins and their annotated locations for NP_001152968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC142103
      Consensus CDS
      CCDS50199.1
      UniProtKB/TrEMBL
      A0A8C6MU12, Q99NF7
      Related
      ENSMUSP00000079107.7, ENSMUST00000080217.14
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    2. NM_001159497.1NP_001152969.1  protein phosphatase 1B isoform 3

      See identical proteins and their annotated locations for NP_001152969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BB615769, BQ176513, D45860
      Consensus CDS
      CCDS50201.1
      UniProtKB/Swiss-Prot
      P36993
      UniProtKB/TrEMBL
      A0A8C6GX10
      Related
      ENSMUSP00000107924.4, ENSMUST00000112305.10
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    3. NM_001159498.3NP_001152970.1  protein phosphatase 1B isoform 4

      See identical proteins and their annotated locations for NP_001152970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC142103
      Consensus CDS
      CCDS50200.1
      UniProtKB/Swiss-Prot
      P36993
      UniProtKB/TrEMBL
      A0A8C6GY52
      Related
      ENSMUSP00000157282.2, ENSMUST00000234540.2
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    4. NM_001411569.1NP_001398498.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    5. NM_001411570.1NP_001398499.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    6. NM_001411571.1NP_001398500.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    7. NM_001411572.1NP_001398501.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    8. NM_001411573.1NP_001398502.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    9. NM_001411574.1NP_001398503.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    10. NM_001411576.1NP_001398505.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    11. NM_001411577.1NP_001398506.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    12. NM_001411578.1NP_001398507.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    13. NM_001411579.1NP_001398508.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    14. NM_001411580.1NP_001398509.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    15. NM_001411581.1NP_001398510.1  protein phosphatase 1B

      Status: VALIDATED

      Source sequence(s)
      AC142103
    16. NM_011151.3NP_035281.1  protein phosphatase 1B isoform 2

      See identical proteins and their annotated locations for NP_035281.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variant 2 uses an alternate 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC142103
      Consensus CDS
      CCDS37710.1
      UniProtKB/Swiss-Prot
      P36993
      UniProtKB/TrEMBL
      A0A8C6MUD0, Q546R1, Q99NF7
      Related
      ENSMUSP00000107923.3, ENSMUST00000112304.10
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

    RNA

    1. NR_177287.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC142103

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      85264169..85331420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249594.2XP_030105454.1  protein phosphatase 1B isoform X3

      UniProtKB/TrEMBL
      A0A8C6GX10
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    2. XM_030249592.2XP_030105452.1  protein phosphatase 1B isoform X2

      UniProtKB/TrEMBL
      A0A8C6GY52
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    3. XM_011246321.3XP_011244623.1  protein phosphatase 1B isoform X1

      UniProtKB/TrEMBL
      A0A8C6MU12, Q99NF7
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    4. XM_006523861.4XP_006523924.1  protein phosphatase 1B isoform X2

      UniProtKB/Swiss-Prot
      P36993
      UniProtKB/TrEMBL
      A0A8C6GY52
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    5. XM_006523862.4XP_006523925.1  protein phosphatase 1B isoform X3

      UniProtKB/Swiss-Prot
      P36993
      UniProtKB/TrEMBL
      A0A8C6GX10
      Related
      ENSMUSP00000157013.2, ENSMUST00000234332.2
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    6. XM_036160413.1XP_036016306.1  protein phosphatase 1B isoform X2

      UniProtKB/TrEMBL
      A0A8C6GY52
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    7. XM_030249593.2XP_030105453.1  protein phosphatase 1B isoform X3

      UniProtKB/TrEMBL
      A0A8C6GX10
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    8. XM_036160415.1XP_036016308.1  protein phosphatase 1B isoform X3

      UniProtKB/TrEMBL
      A0A8C6GX10
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    9. XM_036160414.1XP_036016307.1  protein phosphatase 1B isoform X2

      UniProtKB/TrEMBL
      A0A8C6GY52
      Related
      ENSMUSP00000107926.4, ENSMUST00000112307.4
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289368
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    10. XM_011246322.3XP_011244624.1  protein phosphatase 1B isoform X1

      See identical proteins and their annotated locations for XP_011244624.1

      UniProtKB/TrEMBL
      A0A8C6MU12, Q99NF7
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
    11. XM_006523860.4XP_006523923.1  protein phosphatase 1B isoform X1

      See identical proteins and their annotated locations for XP_006523923.1

      UniProtKB/TrEMBL
      A0A8C6MU12, Q99NF7
      Conserved Domains (2) summary
      cd00143
      Location:23295
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
      pfam07830
      Location:289365
      PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain