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    Ppara peroxisome proliferator activated receptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 19013, updated on 9-Jul-2024

    Summary

    Official Symbol
    Pparaprovided by MGI
    Official Full Name
    peroxisome proliferator activated receptor alphaprovided by MGI
    Primary source
    MGI:MGI:104740
    See related
    Ensembl:ENSMUSG00000022383 AllianceGenome:MGI:104740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppar; Nr1c1; PPARalpha; PPAR-alpha; 4933429D07Rik
    Summary
    Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and lipid binding activity. Involved in several processes, including negative regulation of appetite; positive regulation of fatty acid oxidation; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of cellular biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Is expressed in several structures, including adipose tissue; early conceptus; heart; liver; and oocyte. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver adult (RPKM 11.2), kidney adult (RPKM 8.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppara in Genome Data Viewer
    Location:
    15 E2; 15 40.42 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85619112..85691052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85734910..85806851)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34622 Neighboring gene predicted gene, 46529 Neighboring gene STARR-positive B cell enhancer ABC_E10873 Neighboring gene STARR-seq mESC enhancer starr_39399 Neighboring gene STARR-positive B cell enhancer ABC_E5505 Neighboring gene cysteine rich, DPF motif domain containing 1 Neighboring gene polycystin (PKD) family receptor for egg jelly

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NFAT protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear steroid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear steroid receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within enamel mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cholesterol storage IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transformation of host cell by virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cellular ketone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    peroxisome proliferator-activated receptor alpha
    Names
    nuclear receptor subfamily 1 group C member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113418.1NP_001106889.1  peroxisome proliferator-activated receptor alpha

      See identical proteins and their annotated locations for NP_001106889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117784, AI118064, AK081709
      Consensus CDS
      CCDS27721.1
      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000105050.2, ENSMUST00000109423.8
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. NM_011144.6NP_035274.2  peroxisome proliferator-activated receptor alpha

      See identical proteins and their annotated locations for NP_035274.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC117784, AI118064, AK035676
      Consensus CDS
      CCDS27721.1
      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000105049.2, ENSMUST00000109422.8
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      85619112..85691052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245517.4XP_011243819.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_011243819.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    2. XM_030248422.2XP_030104282.1  peroxisome proliferator-activated receptor alpha isoform X3

      Conserved Domains (2) summary
      cd06932
      Location:36302
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    3. XM_030248424.2XP_030104284.1  peroxisome proliferator-activated receptor alpha isoform X3

      Conserved Domains (2) summary
      cd06932
      Location:36302
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. XM_030248421.2XP_030104281.1  peroxisome proliferator-activated receptor alpha isoform X2

      Conserved Domains (2) summary
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
      cl11397
      Location:201386
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    5. XM_011245516.4XP_011243818.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_011243818.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    6. XM_006520619.3XP_006520682.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006520682.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Related
      ENSMUSP00000059719.6, ENSMUST00000057979.6
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    7. XM_030248423.2XP_030104283.1  peroxisome proliferator-activated receptor alpha isoform X3

      Conserved Domains (2) summary
      cd06932
      Location:36302
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cl02596
      Location:119
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    8. XM_011245519.4XP_011243821.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_011243821.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    9. XM_006520623.5XP_006520686.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006520686.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    10. XM_006520621.5XP_006520684.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006520684.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    11. XM_006520620.5XP_006520683.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006520683.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    12. XM_006520622.5XP_006520685.1  peroxisome proliferator-activated receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006520685.1

      UniProtKB/Swiss-Prot
      P23204
      UniProtKB/TrEMBL
      Q542P9
      Conserved Domains (2) summary
      cd06932
      Location:201467
      NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
      cd06965
      Location:101184
      NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers