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    Plpp1 phospholipid phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19012, updated on 23-Jun-2021

    Summary

    Official Symbol
    Plpp1provided by MGI
    Official Full Name
    phospholipid phosphatase 1provided by MGI
    Primary source
    MGI:MGI:108412
    See related
    Ensembl:ENSMUSG00000021759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    L; P; m; LP; Hpic; LPP1; mPAP; Hic53; LPP-1; PAP2a; Hpic53; PAP-2a; Ppap2a; PAP2-alpha
    Expression
    Ubiquitous expression in adrenal adult (RPKM 77.1), lung adult (RPKM 58.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Plpp1 in Genome Data Viewer
    Location:
    13; 13 D2.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (112937311..113004428)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (112800777..112867894)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (113591000..113657888)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 38, member 9 Neighboring gene heterogeneous nuclear ribonucleoprotein R pseudogene Neighboring gene predicted gene, 41067 Neighboring gene Mtr4 exosome RNA helicase Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 29 Neighboring gene 40S ribosomal protein S13-like Neighboring gene cyclin O

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ceramide-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diacylglycerol diphosphate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables diacylglycerol diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lipid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidate phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphatidate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables phosphatidate phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables sphingosine-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sphingosine-1-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ceramide metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ceramide metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within diacylglycerol biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipid dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phospholipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sphingosine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sphingosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sphingosine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipid phosphatase 1
    Names
    35 kDa PAP
    hydrogen peroxide inducible protein 53
    lipid phosphate phosphohydrolase 1
    phosphatidate phosphohydrolase type 2a
    phosphatidic acid phosphatase 2a
    phosphatidic acid phosphatase type 2A
    NP_032273.1
    NP_032929.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008247.3NP_032273.1  phospholipid phosphatase 1 isoform 1

      See identical proteins and their annotated locations for NP_032273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB851583, BC061161, CD742481
      Consensus CDS
      CCDS26776.1
      UniProtKB/Swiss-Prot
      Q61469
      Related
      ENSMUSP00000016144.5, ENSMUST00000016144.12
      Conserved Domains (1) summary
      cd03384
      Location:99244
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    2. NM_008903.2NP_032929.1  phospholipid phosphatase 1 isoform 2

      See identical proteins and their annotated locations for NP_032929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks one exon and contains an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BB851583, BY094239, CD742481, D84376
      Consensus CDS
      CCDS26777.1
      UniProtKB/Swiss-Prot
      Q61469
      Related
      ENSMUSP00000064423.7, ENSMUST00000070951.8
      Conserved Domains (1) summary
      cd03384
      Location:98243
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      112937311..113004428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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