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    Cnot7 CCR4-NOT transcription complex, subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 18983, updated on 14-Sep-2021

    Summary

    Official Symbol
    Cnot7provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 7provided by MGI
    Primary source
    MGI:MGI:1298230
    See related
    Ensembl:ENSMUSG00000031601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Caf; Caf1; Pop2; CAF-1; AU022737
    Expression
    Broad expression in CNS E14 (RPKM 22.0), CNS E18 (RPKM 21.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Cnot7 in Genome Data Viewer
    Location:
    8; 8 A4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (40945579..40968888, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40492538..40515847, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (41578390..41596658, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 20 Neighboring gene microRNA 7666 Neighboring gene mitochondrial calcium uptake family, member 3 Neighboring gene zinc finger, DHHC domain containing 2 Neighboring gene vacuolar protein sorting 37A Neighboring gene myotubularin related protein 7 Neighboring gene a disintegrin and metallopeptidase domain 24 (testase 1)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within P-body assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exonucleolytic catabolism of deadenylated mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic catabolism of deadenylated mRNA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene silencing by RNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 7
    Names
    CCR4-associated factor 1
    POP2 homolog
    catabolite repressor protein (CCR4)-associative factor 1
    NP_001258471.1
    NP_001258472.1
    NP_001348867.1
    NP_001348868.1
    NP_035265.1
    XP_006509370.1
    XP_036009723.1
    XP_036009724.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271542.1NP_001258471.1  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_001258471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC118012, AK135669, AK147048
      Consensus CDS
      CCDS22253.1
      UniProtKB/Swiss-Prot
      Q60809
      UniProtKB/TrEMBL
      Q543X5
      Related
      ENSMUSP00000122933.2, ENSMUST00000132032.8
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    2. NM_001271543.1NP_001258472.1  CCR4-NOT transcription complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001258472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC118012
      Consensus CDS
      CCDS72114.1
      UniProtKB/TrEMBL
      Q3TLK9
      Related
      ENSMUSP00000119319.2, ENSMUST00000135269.8
      Conserved Domains (1) summary
      cl23804
      Location:1215
      CAF1; CAF1 family ribonuclease
    3. NM_001361938.1NP_001348867.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CN663584
      Consensus CDS
      CCDS22253.1
      Related
      ENSMUSP00000117304.2, ENSMUST00000149992.2
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    4. NM_001361939.1NP_001348868.1  CCR4-NOT transcription complex subunit 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CJ166755
      Conserved Domains (1) summary
      cl23804
      Location:1292
      CAF1; CAF1 family ribonuclease
    5. NM_011135.5NP_035265.1  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_035265.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform . Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AC118012, AK147048, CJ166755
      Consensus CDS
      CCDS22253.1
      UniProtKB/Swiss-Prot
      Q60809
      UniProtKB/TrEMBL
      Q543X5
      Related
      ENSMUSP00000034012.4, ENSMUST00000034012.10
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease

    RNA

    1. NR_155265.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CJ166755, CN663584, DV653062
    2. NR_155266.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC118012, AK147048, CN663584, DV653062

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      40945579..40968888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153830.1XP_036009723.1  CCR4-NOT transcription complex subunit 7 isoform X1

      Conserved Domains (1) summary
      cl23804
      Location:1228
      CAF1; CAF1 family ribonuclease
    2. XM_036153831.1XP_036009724.1  CCR4-NOT transcription complex subunit 7 isoform X2

      Conserved Domains (1) summary
      cl23804
      Location:1215
      CAF1; CAF1 family ribonuclease
    3. XM_006509307.3XP_006509370.1  CCR4-NOT transcription complex subunit 7 isoform X3

      Conserved Domains (1) summary
      cl23804
      Location:1173
      CAF1; CAF1 family ribonuclease

    RNA

    1. XR_378909.4 RNA Sequence

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