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    Pold2 polymerase (DNA directed), delta 2, regulatory subunit [ Mus musculus (house mouse) ]

    Gene ID: 18972, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pold2provided by MGI
    Official Full Name
    polymerase (DNA directed), delta 2, regulatory subunitprovided by MGI
    Primary source
    MGI:MGI:1097163
    See related
    Ensembl:ENSMUSG00000020471 Vega:OTTMUSG00000005094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; 50kDa; po1D2
    Expression
    Broad expression in adrenal adult (RPKM 221.0), mammary gland adult (RPKM 85.3) and 22 other tissues See more
    Orthologs

    Genomic context

    See Pold2 in Genome Data Viewer
    Location:
    11; 11 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (5872180..5878256, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (5772183..5778259, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 2 Neighboring gene polymerase (DNA directed), mu Neighboring gene AE binding protein 1 Neighboring gene myosin, light polypeptide 7, regulatory Neighboring gene glucokinase Neighboring gene predicted gene 11967

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA polymerase delta subunit 2
    Names
    DNA polymerase delta subunit p50
    NP_032920.2
    XP_006514650.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361942.1NP_001348871.1  DNA polymerase delta subunit 2

      Status: VALIDATED

      Source sequence(s)
      AL627069, AV329456, BM946479, BQ840484, CX565680
      Conserved Domains (1) summary
      cd07387
      Location:215452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
    2. NM_008894.2NP_032920.2  DNA polymerase delta subunit 2

      See identical proteins and their annotated locations for NP_032920.2

      Status: VALIDATED

      Source sequence(s)
      BG078511, BM215242, BY093766, BY668936, CB205181
      Consensus CDS
      CCDS24407.1
      UniProtKB/Swiss-Prot
      O35654
      Related
      ENSMUSP00000099986.3, OTTMUSP00000005307, ENSMUST00000102922.9, OTTMUST00000011387
      Conserved Domains (1) summary
      cd07387
      Location:215452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      5872180..5878256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514587.3XP_006514650.1  DNA polymerase delta subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      O35654
      Conserved Domains (1) summary
      cd07387
      Location:215452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain
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