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    Pola2 polymerase (DNA directed), alpha 2 [ Mus musculus (house mouse) ]

    Gene ID: 18969, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pola2provided by MGI
    Official Full Name
    polymerase (DNA directed), alpha 2provided by MGI
    Primary source
    MGI:MGI:99690
    See related
    Ensembl:ENSMUSG00000024833
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI573378
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 23.1), liver E14 (RPKM 19.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pola2 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5990571..6014266, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5940543..5964238, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5940543..5964206, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42067 Neighboring gene CDC42 effector protein (Rho GTPase binding) 2 Neighboring gene solute carrier family 22 (organic anion transporter), member 20 Neighboring gene predicted gene, 31719 Neighboring gene calpain 1 Neighboring gene predicted gene 10814

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase alpha subunit B
    Names
    DNA polymerase alpha 2, 68 kDa
    DNA polymerase alpha 70 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164057.1NP_001157529.1  DNA polymerase alpha subunit B isoform 2

      See identical proteins and their annotated locations for NP_001157529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS50362.1
      UniProtKB/TrEMBL
      Q8C2T6
      Related
      ENSMUSP00000128866.2, ENSMUST00000165143.3
      Conserved Domains (2) summary
      pfam04042
      Location:343549
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:20238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    2. NM_008893.3NP_032919.2  DNA polymerase alpha subunit B isoform 1

      See identical proteins and their annotated locations for NP_032919.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK150099, AV373556, BY307672
      Consensus CDS
      CCDS29485.1
      UniProtKB/Swiss-Prot
      P33611
      Related
      ENSMUSP00000025752.8, ENSMUST00000025752.15
      Conserved Domains (2) summary
      pfam04042
      Location:343549
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:20238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5990571..6014266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531681.4XP_006531744.1  DNA polymerase alpha subunit B isoform X2

      Conserved Domains (2) summary
      pfam04042
      Location:343592
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:21238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    2. XM_011248610.3XP_011246912.1  DNA polymerase alpha subunit B isoform X5

      Conserved Domains (2) summary
      pfam04042
      Location:358564
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:21253
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    3. XM_011248607.3XP_011246909.1  DNA polymerase alpha subunit B isoform X1

      Conserved Domains (2) summary
      pfam04042
      Location:358607
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:21253
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    4. XM_030250775.2XP_030106635.1  DNA polymerase alpha subunit B isoform X8

      Conserved Domains (2) summary
      pfam04042
      Location:303509
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:15198
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    5. XM_006531683.5XP_006531746.1  DNA polymerase alpha subunit B isoform X6

      Conserved Domains (2) summary
      pfam04042
      Location:303552
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:15198
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    6. XM_011248609.3XP_011246911.1  DNA polymerase alpha subunit B isoform X4

      Conserved Domains (2) summary
      pfam04042
      Location:318567
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:15213
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    7. XM_030250776.1XP_030106636.1  DNA polymerase alpha subunit B isoform X9

      Conserved Domains (1) summary
      pfam04042
      Location:135341
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    8. XM_006531684.5XP_006531747.1  DNA polymerase alpha subunit B isoform X10

      Conserved Domains (1) summary
      pfam04042
      Location:40289
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
    9. XM_030250774.2XP_030106634.1  DNA polymerase alpha subunit B isoform X7

      Conserved Domains (2) summary
      pfam04042
      Location:358564
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:21253
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal
    10. XM_011248608.4XP_011246910.1  DNA polymerase alpha subunit B isoform X3

      Conserved Domains (2) summary
      pfam04042
      Location:358607
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:21253
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RNA

    1. XR_004940121.1 RNA Sequence

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