Format

Send to:

Choose Destination
    • Showing Current items.

    Pola1 polymerase (DNA directed), alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 18968, updated on 19-Jul-2021

    Summary

    Official Symbol
    Pola1provided by MGI
    Official Full Name
    polymerase (DNA directed), alpha 1provided by MGI
    Primary source
    MGI:MGI:99660
    See related
    Ensembl:ENSMUSG00000006678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pola; AW321876
    Expression
    Broad expression in CNS E11.5 (RPKM 4.9), liver E14 (RPKM 4.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pola1 in Genome Data Viewer
    Location:
    X C3; X 41.06 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (92348372..92675993, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (93304766..93632387, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (90550105..90877494, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23454 Neighboring gene aristaless related homeobox Neighboring gene predicted gene, 35587 Neighboring gene valyl-tRNA synthetase pseudogene Neighboring gene predicted gene, 23557 Neighboring gene predicted pseudogene 6985 Neighboring gene phosphate cytidylyltransferase 1, choline, beta isoform Neighboring gene predicted gene, 35641

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables purine nucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables purine nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrimidine nucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables pyrimidine nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication, synthesis of RNA primer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA replication, synthesis of RNA primer ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA strand elongation involved in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA synthesis involved in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lagging strand elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leading strand elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of alpha DNA polymerase:primase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA polymerase alpha catalytic subunit
    Names
    DNA polymerase alpha 1, 180 kDa
    DNA polymerase alpha catalytic subunit p180
    G7a/Bat6Hom
    polymerase, alpha 1
    NP_032918.1
    XP_006527968.1
    XP_036017749.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008892.2NP_032918.1  DNA polymerase alpha catalytic subunit

      See identical proteins and their annotated locations for NP_032918.1

      Status: VALIDATED

      Source sequence(s)
      BC138047, CJ133126, D17384
      Consensus CDS
      CCDS30272.1
      UniProtKB/Swiss-Prot
      P33609
      UniProtKB/TrEMBL
      B9EHJ9
      Related
      ENSMUSP00000006856.3, ENSMUST00000006856.3
      Conserved Domains (5) summary
      cd05776
      Location:539771
      DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
      cd05532
      Location:8361246
      POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
      TIGR00592
      Location:561229
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:12691458
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
      pfam12254
      Location:41101
      DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      92348372..92675993 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161856.1XP_036017749.1  DNA polymerase alpha catalytic subunit isoform X2

      Conserved Domains (2) summary
      TIGR00592
      Location:11087
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:11271316
      zf-DNA_Pol; DNA Polymerase alpha zinc finger
    2. XM_006527905.5XP_006527968.1  DNA polymerase alpha catalytic subunit isoform X1

      Conserved Domains (2) summary
      TIGR00592
      Location:561229
      pol2; DNA polymerase (pol2)
      pfam08996
      Location:12691386
      zf-DNA_Pol; DNA Polymerase alpha zinc finger

    RNA

    1. XR_003953001.1 RNA Sequence

    2. XR_004940329.1 RNA Sequence

    3. XR_878096.4 RNA Sequence

    Support Center