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    Pnp purine-nucleoside phosphorylase [ Mus musculus (house mouse) ]

    Gene ID: 18950, updated on 31-Jan-2019

    Summary

    Official Symbol
    Pnpprovided by MGI
    Official Full Name
    purine-nucleoside phosphorylaseprovided by MGI
    Primary source
    MGI:MGI:97365
    See related
    Ensembl:ENSMUSG00000115338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np; Np-1; Np-2; Pnp1; AL024301; AU015798
    Expression
    Broad expression in placenta adult (RPKM 51.3), large intestine adult (RPKM 50.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Pnp in Genome Data Viewer
    Location:
    14 C1; 14 26.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (50944303..50953412)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51563978..51573087)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene purine-nucleoside phosphorylase 2 Neighboring gene predicted gene 8518

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoside binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleobase binding ISO
    Inferred from Sequence Orthology
    more info
     
    purine-nucleoside phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    purine-nucleoside phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    purine-nucleoside phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    purine-nucleoside phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring pentosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic mitochondrial changes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dGTP metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    deoxyguanosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    deoxyinosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    guanosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inosine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    purine nucleoside metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    purine nucleoside metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    purine nucleoside metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    purine nucleoside phosphorylase
    Names
    inosine phosphorylase
    inosine-guanosine phosphorylase
    purine-nucleoside phosphorylase 1
    NP_038660.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013632.4NP_038660.1  purine nucleoside phosphorylase

      See identical proteins and their annotated locations for NP_038660.1

      Status: VALIDATED

      Source sequence(s)
      AK049817, AK153451, BB613747
      Consensus CDS
      CCDS27029.1
      UniProtKB/Swiss-Prot
      P23492
      UniProtKB/TrEMBL
      Q543K9
      Related
      ENSMUSP00000043926.6, ENSMUST00000048615.12
      Conserved Domains (2) summary
      COG0005
      Location:11283
      XapA; Purine nucleoside phosphorylase [Nucleotide transport and metabolism]
      TIGR01700
      Location:26280
      PNPH; purine nucleoside phosphorylase I, inosine and guanosine-specific

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      50944303..50953412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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