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    Plxna1 plexin A1 [ Mus musculus (house mouse) ]

    Gene ID: 18844, updated on 26-Sep-2022

    Summary

    Official Symbol
    Plxna1provided by MGI
    Official Full Name
    plexin A1provided by MGI
    Primary source
    MGI:MGI:107685
    See related
    Ensembl:ENSMUSG00000030084 AllianceGenome:MGI:107685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NOV; Plxn1; PlexA1; mKIAA4053; 2600013D04Rik
    Summary
    Enables semaphorin receptor activity. Acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in membrane. Is expressed in several structures, including central nervous system; cranial nerve; genitourinary system; lung; and sensory organ. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 77.1), ovary adult (RPKM 54.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Plxna1 in Genome Data Viewer
    Location:
    6; 6 D1
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (89293295..89339595, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (89316313..89362613, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1516 Neighboring gene RIKEN cDNA 4930512J16 gene Neighboring gene predicted gene, 36735 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 6 Neighboring gene predicted gene, 52910 Neighboring gene predicted gene, 46966

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA4053

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables semaphorin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables semaphorin receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dichotomous subdivision of terminal units involved in salivary gland branching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory nerve formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of semaphorin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    plexin-A1
    Names
    plex 1
    plexin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008881.2NP_032907.1  plexin-A1 precursor

      See identical proteins and their annotated locations for NP_032907.1

      Status: VALIDATED

      Source sequence(s)
      AK220460, BC138023, CF734847, CJ111942
      Consensus CDS
      CCDS20344.1
      UniProtKB/Swiss-Prot
      P70206, Q5DTR0
      Related
      ENSMUSP00000131840.2, ENSMUST00000163139.8
      Conserved Domains (7) summary
      cd11271
      Location:36511
      Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1
      cd01179
      Location:9591044
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:862958
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:10461146
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:512554
      PSI; Plexin repeat
      pfam01833
      Location:11481232
      TIG; IPT/TIG domain
      pfam08337
      Location:13161864
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      89293295..89339595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)