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    Pld1 phospholipase D1 [ Mus musculus (house mouse) ]

    Gene ID: 18805, updated on 17-Oct-2021

    Summary

    Official Symbol
    Pld1provided by MGI
    Official Full Name
    phospholipase D1provided by MGI
    Primary source
    MGI:MGI:109585
    See related
    Ensembl:ENSMUSG00000027695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pld1a; Pld1b; mPLD1; C85393; AA536939
    Expression
    Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pld1 in Genome Data Viewer
    Location:
    3 A3; 3 11.15 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (27992636..28187511)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (27938459..28133362)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (27837602..28032284)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene predicted gene, 42195 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene TRAF2 and NCK interacting kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase D activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase D1
    Names
    PLD 1
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    NP_001157528.1
    NP_001355596.1
    NP_032901.2
    XP_017174978.1
    XP_017174979.1
    XP_017174980.1
    XP_036018836.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164056.1NP_001157528.1  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_001157528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132149, AK136111, BC068144
      Consensus CDS
      CCDS17275.1
      UniProtKB/TrEMBL
      Q3UWT7, Q6NVF2
      Related
      ENSMUSP00000113810.2, ENSMUST00000120834.8
      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D
    2. NM_001368667.1NP_001355596.1  phospholipase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114987, AC132149
      Consensus CDS
      CCDS89617.1
      Related
      ENSMUSP00000118727.3, ENSMUST00000123539.8
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    3. NM_008875.4NP_032901.2  phospholipase D1 isoform 1

      See identical proteins and their annotated locations for NP_032901.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136111, BC068144, CF727963
      Consensus CDS
      CCDS17275.1
      UniProtKB/TrEMBL
      Q3UWT7, Q6NVF2
      Related
      ENSMUSP00000064694.5, ENSMUST00000067757.11
      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      27992636..28187511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319490.3XP_017174979.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    2. XM_017319489.3XP_017174978.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
    3. XM_036162943.1XP_036018836.1  phospholipase D1 isoform X2

      Conserved Domains (1) summary
      PLN02866
      Location:821021
      PLN02866; phospholipase D
    4. XM_017319491.3XP_017174980.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (1) summary
      PLN02866
      Location:821059
      PLN02866; phospholipase D
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