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    Pld1 phospholipase D1 [ Mus musculus (house mouse) ]

    Gene ID: 18805, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pld1provided by MGI
    Official Full Name
    phospholipase D1provided by MGI
    Primary source
    MGI:MGI:109585
    See related
    Ensembl:ENSMUSG00000027695 Vega:OTTMUSG00000028207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pld1a; Pld1b; mPLD1; C85393; AA536939
    Expression
    Broad expression in large intestine adult (RPKM 8.9), bladder adult (RPKM 4.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See Pld1 in Genome Data Viewer
    Location:
    3 A3; 3 11.15 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (27938407..28133362)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (27837602..28032284)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 212 Neighboring gene predicted gene, 42195 Neighboring gene predicted gene, 42196 Neighboring gene TRAF2 and NCK interacting kinase Neighboring gene microRNA 466q

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inositol lipid-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phospholipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle cycle ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipase D1
    Names
    PLD 1
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    NP_001157528.1
    NP_032901.2
    XP_006535477.1
    XP_017174978.1
    XP_017174979.1
    XP_017174980.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164056.1NP_001157528.1  phospholipase D1

      See identical proteins and their annotated locations for NP_001157528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC132149, AK136111, BC068144
      Consensus CDS
      CCDS17275.1
      UniProtKB/TrEMBL
      Q3UWT7, Q6NVF2
      Related
      ENSMUSP00000113810.1, OTTMUSP00000035546, ENSMUST00000120834.7, OTTMUST00000069877
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821021
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    2. NM_008875.4NP_032901.2  phospholipase D1

      See identical proteins and their annotated locations for NP_032901.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK136111, BC068144, CF727963
      Consensus CDS
      CCDS17275.1
      UniProtKB/TrEMBL
      Q3UWT7, Q6NVF2
      Related
      ENSMUSP00000064694.4, OTTMUSP00000035547, ENSMUST00000067757.10, OTTMUST00000069878
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821021
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      27938407..28133362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319490.1XP_017174979.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821059
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    2. XM_017319489.1XP_017174978.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821059
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    3. XM_017319491.1XP_017174980.1  phospholipase D1 isoform X1

      UniProtKB/TrEMBL
      D6RH77
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821059
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    4. XM_006535414.3XP_006535477.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_006535477.1

      UniProtKB/TrEMBL
      D6RH77
      Related
      ENSMUSP00000118727.2, OTTMUSP00000035549, ENSMUST00000123539.7, OTTMUST00000069880
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821059
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
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