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    Plcb3 phospholipase C, beta 3 [ Mus musculus (house mouse) ]

    Gene ID: 18797, updated on 5-Sep-2021

    Summary

    Official Symbol
    Plcb3provided by MGI
    Official Full Name
    phospholipase C, beta 3provided by MGI
    Primary source
    MGI:MGI:104778
    See related
    Ensembl:ENSMUSG00000024960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4098
    Expression
    Broad expression in large intestine adult (RPKM 158.9), duodenum adult (RPKM 122.8) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Plcb3 in Genome Data Viewer
    Location:
    19 A; 19 5.1 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6931081..6951738, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6953708..6975006, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (7028203..7044242, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2-associated agonist of cell death Neighboring gene ATG2 autophagy related 2 homolog A pseudogene Neighboring gene predicted gene, 52400 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 14B Neighboring gene predicted gene, 51400 Neighboring gene FK506 binding protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4098

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inositol trisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
    Names
    PLC-beta-3
    phosphoinositide phospholipase C-beta-3
    NP_001277278.1
    NP_032900.2
    XP_006526829.1
    XP_006526830.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290349.1NP_001277278.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform a

      See identical proteins and their annotated locations for NP_001277278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC120557, AI851116, AK146793
      Consensus CDS
      CCDS70925.1
      UniProtKB/Swiss-Prot
      P51432
      Related
      ENSMUSP00000025912.9, ENSMUST00000025912.10
      Conserved Domains (6) summary
      cd00275
      Location:729844
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316694
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:22149
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:10291202
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:225315
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl12013
      Location:9761118
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_008874.4NP_032900.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform b

      See identical proteins and their annotated locations for NP_032900.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate splice sites that result in an alternate codon in the 5' coding region, compared to variant 1. The encoded isoform (b) is the same length as isoform a.
      Source sequence(s)
      AC120557, AI851116, AK146793, CB527492
      UniProtKB/Swiss-Prot
      P51432
      UniProtKB/TrEMBL
      Q8CI86
      Conserved Domains (6) summary
      cd00275
      Location:729844
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:316694
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:22149
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam08703
      Location:10291202
      PLC-beta_C; PLC-beta C terminal
      pfam09279
      Location:225315
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl12013
      Location:9761153
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6931081..6951738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526767.5XP_006526830.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2

      Conserved Domains (6) summary
      cd08591
      Location:286664
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:288804
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:4119
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16210
      Location:124274
      EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
      pfam06631
      Location:922959
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:9991172
      PLC-beta_C; PLC-beta C terminal
    2. XM_006526766.5XP_006526829.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1

      See identical proteins and their annotated locations for XP_006526829.1

      Conserved Domains (6) summary
      cd08591
      Location:314692
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02952
      Location:316832
      PLN02952; phosphoinositide phospholipase C
      cd13361
      Location:32147
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16210
      Location:152302
      EFh_PI-PLCbeta3; EF-hand motif found in phosphoinositide phospholipase C beta 3 (PI-PLC-beta3)
      pfam06631
      Location:950987
      DUF1154; Protein of unknown function (DUF1154)
      pfam08703
      Location:10271200
      PLC-beta_C; PLC-beta C terminal
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