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    Plat plasminogen activator, tissue [ Mus musculus (house mouse) ]

    Gene ID: 18791, updated on 5-Sep-2021

    Summary

    Official Symbol
    Platprovided by MGI
    Official Full Name
    plasminogen activator, tissueprovided by MGI
    Primary source
    MGI:MGI:97610
    See related
    Ensembl:ENSMUSG00000031538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    t; t-; tPA; D8Ertd2; AU020998; AW212668; D8Ertd2e
    Summary
    This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]
    Expression
    Broad expression in ovary adult (RPKM 44.8), subcutaneous fat pad adult (RPKM 41.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Plat in Genome Data Viewer
    Location:
    8 A2; 8 11.42 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (23247655..23272864)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22757722..22782848)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23868216..23893320)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene polymerase (DNA directed), beta Neighboring gene inhibitor of kappaB kinase beta Neighboring gene RIKEN cDNA 1700041G16 gene Neighboring gene adaptor-related protein complex 3, mu 2 subunit Neighboring gene predicted gene, 46036 Neighboring gene predicted gene, 24735

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC18508

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in plasminogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ovulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prevention of polyspermy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in smooth muscle cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in trans-synaptic signaling by BDNF, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tissue-type plasminogen activator
    Names
    t-plasminogen activator
    NP_032898.2
    XP_036009719.1
    XP_036009720.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008872.3NP_032898.2  tissue-type plasminogen activator preproprotein

      See identical proteins and their annotated locations for NP_032898.2

      Status: REVIEWED

      Source sequence(s)
      AC121835, AK135965, CJ146601, DV644940
      Consensus CDS
      CCDS22183.1
      UniProtKB/Swiss-Prot
      P11214
      Related
      ENSMUSP00000033941.6, ENSMUST00000033941.7
      Conserved Domains (5) summary
      smart00058
      Location:3880
      FN1; Fibronectin type 1 domain
      cd00108
      Location:210295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:311556
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:83115
      EGF; EGF-like domain
      pfam00051
      Location:124205
      Kringle; Kringle domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      23247655..23272864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153827.1XP_036009720.1  tissue-type plasminogen activator isoform X2

      Conserved Domains (3) summary
      smart00058
      Location:3880
      FN1; Fibronectin type 1 domain
      cd00108
      Location:84169
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:185430
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_036153826.1XP_036009719.1  tissue-type plasminogen activator isoform X1

      Conserved Domains (5) summary
      smart00058
      Location:3880
      FN1; Fibronectin type 1 domain
      cd00108
      Location:210295
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
      cd00190
      Location:311556
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00008
      Location:83115
      EGF; EGF-like domain
      pfam00051
      Location:124205
      Kringle; Kringle domain
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