Format

Send to:

Choose Destination
    • Showing Current items.

    Papola poly (A) polymerase alpha [ Mus musculus (house mouse) ]

    Gene ID: 18789, updated on 23-May-2018

    Summary

    Official Symbol
    Papolaprovided by MGI
    Official Full Name
    poly (A) polymerase alphaprovided by MGI
    Primary source
    MGI:MGI:109301
    See related
    Ensembl:ENSMUSG00000021111 Vega:OTTMUSG00000035482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pap; Plap; PapIII
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 35.7), limb E14.5 (RPKM 31.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Papola in Genome Data Viewer
    Location:
    12; 12 E
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (105784674..105838949)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (107022912..107077154)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene GSK3B interacting protein Neighboring gene adenylate kinase 7 Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene predicted gene, 46377

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    polynucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polynucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polynucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    poly(A) polymerase alpha
    Names
    PAP-alpha
    polynucleotide adenylyltransferase
    NP_035242.1
    XP_006515655.1
    XP_006515656.1
    XP_006515657.1
    XP_006515658.1
    XP_006515659.1
    XP_017170481.1
    XP_017170482.1
    XP_017170483.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347440.1NP_001334369.1  poly(A) polymerase alpha isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC158526, AK132704, BC060128, BU056874, BY308303, CF167932, CX200364
      Consensus CDS
      CCDS84000.1
      UniProtKB/TrEMBL
      E9PZR3, Q3V141
      Conserved Domains (3) summary
      pfam04926
      Location:366495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21363
      PAP_central; Poly(A) polymerase central domain
      cl26091
      Location:501647
      MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
    2. NM_011112.4NP_035242.1  poly(A) polymerase alpha isoform 1

      See identical proteins and their annotated locations for NP_035242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC158526, AK132704, BC060128, BU056874, BY308303, CX200364
      Consensus CDS
      CCDS49163.1
      UniProtKB/Swiss-Prot
      Q61183
      UniProtKB/TrEMBL
      Q3V141
      Related
      ENSMUSP00000105527.2, OTTMUSP00000049914, ENSMUST00000109901.8, OTTMUST00000090828
      Conserved Domains (3) summary
      pfam04926
      Location:366495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21363
      PAP_central; Poly(A) polymerase central domain
      cl25496
      Location:530725
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      105784674..105838949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314992.1XP_017170481.1  poly(A) polymerase alpha isoform X3

    2. XM_017314994.1XP_017170483.1  poly(A) polymerase alpha isoform X7

    3. XM_017314993.1XP_017170482.1  poly(A) polymerase alpha isoform X6

      Related
      ENSMUSP00000126275.1, OTTMUSP00000049917, ENSMUST00000170002.7, OTTMUST00000090833
      Conserved Domains (3) summary
      pfam04926
      Location:366495
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:21363
      PAP_central; Poly(A) polymerase central domain
      cl26091
      Location:501647
      MotB_plug; Membrane MotB of proton-channel complex MotA/MotB
    4. XM_006515592.2XP_006515655.1  poly(A) polymerase alpha isoform X2

      Conserved Domains (3) summary
      pfam04926
      Location:380509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35377
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:612681
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    5. XM_006515593.3XP_006515656.1  poly(A) polymerase alpha isoform X4

      Conserved Domains (4) summary
      PTZ00418
      Location:23581
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:380509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35377
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:613682
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    6. XM_006515594.2XP_006515657.1  poly(A) polymerase alpha isoform X5

      Conserved Domains (4) summary
      PTZ00418
      Location:23581
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:380509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35377
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:613682
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    7. XM_006515595.2XP_006515658.1  poly(A) polymerase alpha isoform X8

      Conserved Domains (4) summary
      PTZ00418
      Location:23581
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:380509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35377
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:613682
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb
    8. XM_006515596.3XP_006515659.1  poly(A) polymerase alpha isoform X1

      Conserved Domains (4) summary
      PTZ00418
      Location:23581
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:380509
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:35377
      PAP_central; Poly(A) polymerase central domain
      pfam11035
      Location:613682
      SnAPC_2_like; Small nuclear RNA activating complex subunit 2, SNAP190 Myb

    RNA

    1. XR_381486.2 RNA Sequence

    Support Center