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    Plaa phospholipase A2, activating protein [ Mus musculus (house mouse) ]

    Gene ID: 18786, updated on 23-Jun-2021

    Summary

    Official Symbol
    Plaaprovided by MGI
    Official Full Name
    phospholipase A2, activating proteinprovided by MGI
    Primary source
    MGI:MGI:104810
    See related
    Ensembl:ENSMUSG00000028577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLAP; Ufd3; PLA2P; AI536418; AU018445; AW208417; D4Ertd618; 2410007N06; D4Ertd618e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.7), placenta adult (RPKM 8.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Plaa in Genome Data Viewer
    Location:
    4 C5; 4 43.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94453376..94491696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94565139..94603247, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (94231830..94269938, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12656 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene predicted gene 12657 Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene microRNA 872

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phospholipase A2 activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein K63-linked ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic vesicle recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in prostaglandin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipase A-2-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172695.2NP_766283.2  phospholipase A-2-activating protein

      See identical proteins and their annotated locations for NP_766283.2

      Status: VALIDATED

      Source sequence(s)
      AK075934, AL732597, CA490654, DV646766
      Consensus CDS
      CCDS18359.1
      UniProtKB/Swiss-Prot
      P27612
      Related
      ENSMUSP00000102724.3, ENSMUST00000107107.9
      Conserved Domains (5) summary
      COG2319
      Location:6296
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08324
      Location:536788
      PUL; PUL domain
      pfam09070
      Location:346459
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:69110
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94453376..94491696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163836.1XP_036019729.1  phospholipase A-2-activating protein isoform X1

      Conserved Domains (4) summary
      cd00200
      Location:2154
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1145
      7WD40; WD40 repeat [structural motif]
      pfam08324
      Location:393645
      PUL; PUL domain
      pfam09070
      Location:203316
      PFU; PFU (PLAA family ubiquitin binding)
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