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    Lypla1 lysophospholipase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18777, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lypla1provided by MGI
    Official Full Name
    lysophospholipase 1provided by MGI
    Primary source
    MGI:MGI:1344588
    See related
    Ensembl:ENSMUSG00000025903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; APT-1; LPL-I; Pla1a; Gm39587
    Expression
    Ubiquitous expression in liver adult (RPKM 20.2), placenta adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lypla1 in Genome Data Viewer
    Location:
    1; 1 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (4878046..4916958)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (4807823..4846735)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (4797974..4836816)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (lipoamide) beta pseudogene Neighboring gene mitochondrial ribosomal protein L15 Neighboring gene uncharacterized LOC118567656 Neighboring gene transcription elongation factor A (SII) 1 Neighboring gene high mobility group box 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: Tcea1

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables palmitoyl-(protein) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables palmitoyl-(protein) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables palmitoyl-(protein) hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acyl-protein thioesterase 1
    Names
    lysoPLA I
    lysophopholipase 1
    lysophospholipase I
    phospholipase 1a
    NP_001342641.1
    NP_032892.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355712.1NP_001342641.1  acyl-protein thioesterase 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102311
      Consensus CDS
      CCDS87810.1
      Related
      ENSMUSP00000111191.2, ENSMUST00000115529.8
      Conserved Domains (1) summary
      pfam02230
      Location:11192
      Abhydrolase_2; Phospholipase/Carboxylesterase
    2. NM_008866.3NP_032892.1  acyl-protein thioesterase 1 isoform 1

      See identical proteins and their annotated locations for NP_032892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102311, AK002674, BQ033435
      Consensus CDS
      CCDS14806.1
      UniProtKB/Swiss-Prot
      P97823
      Related
      ENSMUSP00000027036.5, ENSMUST00000027036.11
      Conserved Domains (2) summary
      COG0596
      Location:24155
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam02230
      Location:11226
      Abhydrolase_2; Phospholipase/Carboxylesterase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      4878046..4916958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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