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    Prkd1 protein kinase D1 [ Mus musculus (house mouse) ]

    Gene ID: 18760, updated on 12-Sep-2021

    Summary

    Official Symbol
    Prkd1provided by MGI
    Official Full Name
    protein kinase D1provided by MGI
    Primary source
    MGI:MGI:99879
    See related
    Ensembl:ENSMUSG00000002688
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PKD; Pkc; Prk; PKD1; Pkcm; Prkcm
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 3.1), subcutaneous fat pad adult (RPKM 2.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prkd1 in Genome Data Viewer
    Location:
    12; 12 B3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (50388009..50696075, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (50341226..50649271, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (51442218..51750210, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40419 Neighboring gene predicted gene, 40418 Neighboring gene predicted gene, 34523 Neighboring gene predicted gene, 53719 Neighboring gene RIKEN cDNA 1700008C04 gene Neighboring gene predicted gene, 34581 Neighboring gene predicted gene, 40421

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase D signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein kinase D signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase D1
    Names
    nPKC-D1
    nPKC-mu
    protein kinase C mu type
    protein kinase C, mu
    protein kinase D
    NP_001369743.1
    NP_001369744.1
    NP_001369745.1
    NP_032884.2
    XP_006515649.1
    XP_006515653.1
    XP_006515654.1
    XP_036013143.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382814.1NP_001369743.1  serine/threonine-protein kinase D1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC099603, AC154543, CT009740, CT010578
      Conserved Domains (4) summary
      cd01239
      Location:414541
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:577836
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20839
      Location:138209
      C1_PKD1_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
      cd20842
      Location:235328
      C1_PKD1_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D (PKD) and similar proteins
    2. NM_001382815.1NP_001369744.1  serine/threonine-protein kinase D1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC099603, AC154543, CT010578
    3. NM_001382816.1NP_001369745.1  serine/threonine-protein kinase D1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009740
      Conserved Domains (1) summary
      cl21453
      Location:637
      PKc_like; Protein Kinases, catalytic domain
    4. NM_008858.4NP_032884.2  serine/threonine-protein kinase D1 isoform 1

      See identical proteins and their annotated locations for NP_032884.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC099603, AC154543, CT009740, CT010578
      Consensus CDS
      CCDS49059.1
      UniProtKB/Swiss-Prot
      Q62101
      Related
      ENSMUSP00000002765.8, ENSMUST00000002765.9
      Conserved Domains (5) summary
      smart00220
      Location:593845
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:277326
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:422549
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:585844
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:145194
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RNA

    1. NR_168537.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099603, AC154543, CT009740, CT010578
    2. NR_168538.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    3. NR_168539.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    4. NR_168540.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    5. NR_168541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    6. NR_168542.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    7. NR_168543.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    8. NR_168544.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740
    9. NR_168545.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT009740

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      50388009..50696075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515586.3XP_006515649.1  serine/threonine-protein kinase D1 isoform X1

      Conserved Domains (4) summary
      cd00029
      Location:277326
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:422549
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:584843
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      pfam00130
      Location:145194
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. XM_036157250.1XP_036013143.1  serine/threonine-protein kinase D1 isoform X2

      Conserved Domains (3) summary
      cd01239
      Location:259386
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:422681
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cl00040
      Location:80173
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    3. XM_006515590.5XP_006515653.1  serine/threonine-protein kinase D1 isoform X2

      See identical proteins and their annotated locations for XP_006515653.1

      Conserved Domains (3) summary
      cd01239
      Location:259386
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:422681
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cl00040
      Location:80173
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    4. XM_006515591.3XP_006515654.1  serine/threonine-protein kinase D1 isoform X3

      Conserved Domains (4) summary
      cd00029
      Location:277326
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:422549
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      pfam00130
      Location:145194
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:585747
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_001780432.3 RNA Sequence

    2. XR_001780431.3 RNA Sequence

    3. XR_001780429.3 RNA Sequence

    4. XR_001780428.3 RNA Sequence

    5. XR_004937445.1 RNA Sequence

    6. XR_004937446.1 RNA Sequence

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