Format

Send to:

Choose Destination
    • Showing Current items.

    Pitpna phosphatidylinositol transfer protein, alpha [ Mus musculus (house mouse) ]

    Gene ID: 18738, updated on 18-Sep-2018

    Summary

    Official Symbol
    Pitpnaprovided by MGI
    Official Full Name
    phosphatidylinositol transfer protein, alphaprovided by MGI
    Primary source
    MGI:MGI:99887
    See related
    Ensembl:ENSMUSG00000017781 Vega:OTTMUSG00000006217
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    vb; Pitpn; vibrator
    Summary
    This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 61.1), cortex adult (RPKM 50.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pitpna in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (75588079..75628804)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (75401610..75442280)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene scavenger receptor class F, member 1 Neighboring gene solute carrier family 43, member 2 Neighboring gene microRNA 3971 Neighboring gene RIKEN cDNA 4931413K12 gene Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene myosin IC

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fatty-acyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylcholine transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phospholipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    stearic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol transfer protein alpha isoform
    Names
    PI-TP-alpha
    Pitp alpha
    ptdIns transfer protein alpha
    ptdInsTP alpha

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008850.2NP_032876.1  phosphatidylinositol transfer protein alpha isoform

      See identical proteins and their annotated locations for NP_032876.1

      Status: REVIEWED

      Source sequence(s)
      AK153569, AK168720, BQ176339, BY316588
      Consensus CDS
      CCDS25052.1
      UniProtKB/Swiss-Prot
      P53810
      UniProtKB/TrEMBL
      Q3TGI6, Q5ND42
      Related
      ENSMUSP00000115723.1, OTTMUSP00000006520, ENSMUST00000143219.7, OTTMUST00000014037
      Conserved Domains (1) summary
      cd08888
      Location:3260
      SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      75588079..75628804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center