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    Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma [ Mus musculus (house mouse) ]

    Gene ID: 18717, updated on 5-Sep-2021

    Summary

    Official Symbol
    Pip5k1cprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase, type 1 gammaprovided by MGI
    Primary source
    MGI:MGI:1298224
    See related
    Ensembl:ENSMUSG00000034902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PIP5K; AI115456; AI835305; Pip5kIgamma
    Expression
    Ubiquitous expression in cortex adult (RPKM 65.2), frontal lobe adult (RPKM 55.5) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Pip5k1c in Genome Data Viewer
    Location:
    10; 10 C1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81128669..81155808)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81292835..81319974)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (80755717..80782719)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein-binding, family A, member 3 Neighboring gene microRNA 3057 Neighboring gene tight junction protein 3 Neighboring gene predicted gene 16315 Neighboring gene cactin, spliceosome C complex subunit Neighboring gene thromboxane A2 receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables talin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables talin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
    Names
    PIP5K1-gamma
    phosphatidylinositol 4-phosphate 5-kinase type I gamma
    ptdIns(4)P-5-kinase 1 gamma
    NP_001140159.1
    NP_001280575.1
    NP_001280576.1
    NP_032870.2
    XP_030100812.1
    XP_036011583.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146687.2NP_001140159.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 2

      See identical proteins and their annotated locations for NP_001140159.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 3' coding region, compared to variant 3. The encoded protein (isoform 2) is shorter, compared to isoform 3.
      Source sequence(s)
      AC155937, AI844562, AK041402, BC094665
      Consensus CDS
      CCDS48643.1
      UniProtKB/Swiss-Prot
      O70161
      Related
      ENSMUSP00000124155.2, ENSMUST00000163075.8
      Conserved Domains (1) summary
      smart00330
      Location:103443
      PIPKc; Phosphatidylinositol phosphate kinases
    2. NM_001293646.1NP_001280575.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC155937, AI844562, AK041402, BC094665
      Consensus CDS
      CCDS78865.1
      UniProtKB/Swiss-Prot
      O70161
      UniProtKB/TrEMBL
      F8WHW6
      Related
      ENSMUSP00000038225.9, ENSMUST00000045469.15
      Conserved Domains (1) summary
      smart00330
      Location:103443
      PIPKc; Phosphatidylinositol phosphate kinases
    3. NM_001293647.1NP_001280576.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 4

      See identical proteins and their annotated locations for NP_001280576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' and 3' coding region, and initiates translation at a downstream start codon, compared to variant 3. The encoded protein (isoform 4) is shorter, compared to isoform 3.
      Source sequence(s)
      AC155937, AI844562, AK041402, BC094665
      UniProtKB/Swiss-Prot
      O70161
      Conserved Domains (1) summary
      cd17301
      Location:1342
      PIPKc_PIP5KI; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type I phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinases (PIP5KI) and similar proteins
    4. NM_008844.3NP_032870.2  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform 1

      See identical proteins and their annotated locations for NP_032870.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. The encoded protein (isoform 1) is shorter, compared to isoform 3.
      Source sequence(s)
      AC155937, AI844562, AK041402, BC094665
      Consensus CDS
      CCDS35994.1
      UniProtKB/Swiss-Prot
      O70161
      Related
      ENSMUSP00000100964.4, ENSMUST00000105327.10
      Conserved Domains (1) summary
      smart00330
      Location:103443
      PIPKc; Phosphatidylinositol phosphate kinases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81128669..81155808
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244952.1XP_030100812.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2

      Conserved Domains (1) summary
      cd17301
      Location:1342
      PIPKc_PIP5KI; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type I phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinases (PIP5KI) and similar proteins
    2. XM_036155690.1XP_036011583.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1

      Conserved Domains (1) summary
      cd17301
      Location:1342
      PIPKc_PIP5KI; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type I phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinases (PIP5KI) and similar proteins

    RNA

    1. XR_004936128.1 RNA Sequence

    2. XR_003948618.1 RNA Sequence

    3. XR_003948617.1 RNA Sequence

      Related
      ENSMUST00000161854.8
    4. XR_003948619.1 RNA Sequence

    5. XR_003948616.2 RNA Sequence

    6. XR_380377.4 RNA Sequence

    7. XR_003948621.1 RNA Sequence

    8. XR_003948620.2 RNA Sequence

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