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    Pim1 proviral integration site 1 [ Mus musculus (house mouse) ]

    Gene ID: 18712, updated on 18-Sep-2024

    Summary

    Official Symbol
    Pim1provided by MGI
    Official Full Name
    proviral integration site 1provided by MGI
    Primary source
    MGI:MGI:97584
    See related
    Ensembl:ENSMUSG00000024014 AllianceGenome:MGI:97584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pim-1
    Summary
    Enables ATP binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of brown fat cell differentiation; protein stabilization; and regulation of hematopoietic stem cell proliferation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; primitive streak; and spleen. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 59.9), duodenum adult (RPKM 47.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Pim1 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29709759..29715085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29490785..29496111)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene STARR-positive B cell enhancer ABC_E10944 Neighboring gene STARR-seq mESC enhancer starr_42277 Neighboring gene FYVE, RhoGEF and PH domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_42278 Neighboring gene STARR-positive B cell enhancer ABC_E2478 Neighboring gene STARR-positive B cell enhancer ABC_E8664 Neighboring gene VISTA enhancer mm81 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29574287-29574588 Neighboring gene predicted gene, 36486 Neighboring gene STARR-seq mESC enhancer starr_42287 Neighboring gene predicted gene, 36199 Neighboring gene VISTA enhancer mm755 Neighboring gene predicted gene, 26885 Neighboring gene STARR-positive B cell enhancer ABC_E2479 Neighboring gene STARR-positive B cell enhancer ABC_E5587 Neighboring gene STARR-positive B cell enhancer ABC_E8946 Neighboring gene STARR-positive B cell enhancer ABC_E9949 Neighboring gene transmembrane 217B Neighboring gene transmembrane protein 217 Neighboring gene STARR-seq mESC enhancer starr_42293 Neighboring gene TBC1 domain family, member 22B Neighboring gene TBC1 domain family, member 22B, opposite strand Neighboring gene microRNA 7667

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal small subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to type II interferon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardioblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardioblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vitamin D receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vitamin D receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase pim-1
    Names
    proto-oncogene serine/threonine-protein kinase pim-1
    NP_001351842.1
    NP_032868.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364913.1NP_001351842.1  serine/threonine-protein kinase pim-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163629
      Consensus CDS
      CCDS89050.1
      UniProtKB/TrEMBL
      A0A3Q4EGX3
      Related
      ENSMUSP00000157217.2, ENSMUST00000234665.2
      Conserved Domains (1) summary
      cl21453
      Location:156
      PKc_like; Protein Kinases, catalytic domain
    2. NM_008842.4NP_032868.2  serine/threonine-protein kinase pim-1 isoform 1

      See identical proteins and their annotated locations for NP_032868.2

      Status: VALIDATED

      Source sequence(s)
      AA881360, AC163629, AK158445, BC053019
      Consensus CDS
      CCDS79520.1
      UniProtKB/Swiss-Prot
      F6XDQ5, P06803, Q8CFN8
      Related
      ENSMUSP00000024811.8, ENSMUST00000024811.9
      Conserved Domains (1) summary
      cl21453
      Location:37290
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29709759..29715085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)