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    Pikfyve phosphoinositide kinase, FYVE type zinc finger containing [ Mus musculus (house mouse) ]

    Gene ID: 18711, updated on 5-Sep-2021

    Summary

    Official Symbol
    Pikfyveprovided by MGI
    Official Full Name
    phosphoinositide kinase, FYVE type zinc finger containingprovided by MGI
    Primary source
    MGI:MGI:1335106
    See related
    Ensembl:ENSMUSG00000025949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Pip; p235; Pip5k; Pip5k3; Pipk5k3; PipkIII; 5230400C17Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.4), CNS E18 (RPKM 3.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pikfyve in Genome Data Viewer
    Location:
    1; 1 C3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65225796..65317855)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65186640..65278696)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (65233259..65325270)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D630023F18 gene Neighboring gene predicted gene, 36358 Neighboring gene isocitrate dehydrogenase 1 (NADP+), soluble Neighboring gene parathyroid hormone 2 receptor Neighboring gene predicted gene 28926

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-5-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in melanosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in melanosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within myelin assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in neutrophil degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagosome maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagosome maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagosome-lysosome fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 5-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein targeting to membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor-mediated endocytosis of virus by host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    1-phosphatidylinositol 3-phosphate 5-kinase
    Names
    FYVE finger-containing phosphoinositide kinase
    PIPkin-III
    PtdIns(4)P-5-kinase
    phosphatidylinositol 3-phosphate 5-kinase type III
    phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
    phosphatidylinositol-4-phosphate 5-kinase, type III
    phosphoinositide kinase, FYVE finger containing
    serine-protein kinase PIKFYVE
    type III PIP kinase
    NP_001297553.1
    NP_035216.2
    XP_006495839.1
    XP_006495840.1
    XP_006495842.1
    XP_006495844.1
    XP_006495845.1
    XP_011236756.1
    XP_030108127.1
    XP_030108131.1
    XP_036018669.1
    XP_036018671.1
    XP_036018672.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310624.1NP_001297553.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform 1

      See identical proteins and their annotated locations for NP_001297553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164079, AK173077, BY271210
      Consensus CDS
      CCDS78600.1
      UniProtKB/Swiss-Prot
      Q9Z1T6
      Related
      ENSMUSP00000095314.5, ENSMUST00000097707.5
      Conserved Domains (4) summary
      cd03334
      Location:617877
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18172083
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    2. NM_011086.2NP_035216.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform 2

      See identical proteins and their annotated locations for NP_035216.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC164079, AF102777, AK173077, BY271210
      Consensus CDS
      CCDS35601.1
      UniProtKB/Swiss-Prot
      Q9Z1T6
      UniProtKB/TrEMBL
      D3Z5N5
      Related
      ENSMUSP00000079926.8, ENSMUST00000081154.14
      Conserved Domains (5) summary
      cd00139
      Location:17262039
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:572832
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cl12013
      Location:13531400
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65225796..65317855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238454.4XP_011236756.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

      Conserved Domains (3) summary
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    2. XM_006495776.4XP_006495839.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      See identical proteins and their annotated locations for XP_006495839.1

      Conserved Domains (4) summary
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18292095
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    3. XM_036162776.1XP_036018669.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      Conserved Domains (4) summary
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18012067
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    4. XM_006495782.5XP_006495845.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

      Conserved Domains (4) summary
      cd03334
      Location:573833
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:17732039
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    5. XM_006495779.5XP_006495842.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

      Conserved Domains (4) summary
      cd03334
      Location:628888
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18282094
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    6. XM_036162778.1XP_036018671.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

      Conserved Domains (4) summary
      cd03334
      Location:628888
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18002066
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    7. XM_030252271.2XP_030108131.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

      Conserved Domains (4) summary
      cd03334
      Location:561821
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:17612027
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    8. XM_006495777.5XP_006495840.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      See identical proteins and their annotated locations for XP_006495840.1

      Conserved Domains (4) summary
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18292095
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    9. XM_030252267.2XP_030108127.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

      Conserved Domains (4) summary
      cd03334
      Location:628888
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18282094
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    10. XM_006495781.5XP_006495844.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

      See identical proteins and their annotated locations for XP_006495844.1

      UniProtKB/Swiss-Prot
      Q9Z1T6
      Conserved Domains (4) summary
      cd03334
      Location:617877
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:18172083
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
    11. XM_036162779.1XP_036018672.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

      Conserved Domains (4) summary
      cd03334
      Location:561821
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
      cd17300
      Location:17612027
      PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
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