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    Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 18710, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pik3r3provided by MGI
    Official Full Name
    phosphoinositide-3-kinase regulatory subunit 3provided by MGI
    Primary source
    MGI:MGI:109277
    See related
    Ensembl:ENSMUSG00000028698 Ensembl:ENSMUSG00000111410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p5; p55; p55pik; AA414954
    Expression
    Broad expression in whole brain E14.5 (RPKM 19.3), CNS E14 (RPKM 19.1) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pik3r3 in Genome Data Viewer
    Location:
    4; 4 D1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116078593..116160253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116221400..116303056)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (115894519..115975661)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Pik3r3 upstream reading frame Neighboring gene LLP homolog, pseudogene 1 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene predicted gene, 52760 Neighboring gene IAP promoted placental gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit gamma
    Names
    PI3-kinase regulatory subunit gamma
    PI3-kinase subunit p55-gamma
    PI3K regulatory subunit gamma
    phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
    phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma
    ptdIns-3-kinase regulatory subunit gamma
    ptdIns-3-kinase regulatory subunit p55-gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355584.1NP_001342513.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AK135693, AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CN535899, CV558350, CV562336
      Consensus CDS
      CCDS18509.1
      Conserved Domains (3) summary
      cd09930
      Location:351454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_001355585.1NP_001342514.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CN535899, CV558350, CV562336
      Consensus CDS
      CCDS18509.1
      Conserved Domains (3) summary
      cd09930
      Location:351454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. NM_001355586.1NP_001342515.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL670603, AW457297, BU612070, CA318834, CD350355, CN455231, CN525195, CN528038, CV558350, CV562336
      Related
      ENSMUSP00000150163.2, ENSMUST00000216692.2
      Conserved Domains (3) summary
      cd09930
      Location:307410
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:15123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:128288
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    4. NM_181585.6NP_853616.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_853616.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AK135693, AW457297, BU612070, CA318834, CD350355, CN455231, CV562336
      Consensus CDS
      CCDS18509.1
      UniProtKB/Swiss-Prot
      Q64143
      UniProtKB/TrEMBL
      Q3UXE9
      Related
      ENSMUSP00000030464.8, ENSMUST00000030464.14
      Conserved Domains (3) summary
      cd09930
      Location:351454
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116078593..116160253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502860.5XP_006502923.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006502923.1

      Conserved Domains (3) summary
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:351396
      SH2; Src homology 2 (SH2) domain
    2. XM_006502861.4XP_006502924.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3

      Conserved Domains (3) summary
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:340397
      SH2; Src homology 2 (SH2) domain
    3. XM_006502859.4XP_006502922.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_006502922.1

      Conserved Domains (3) summary
      cd09942
      Location:59167
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:172332
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:351396
      SH2; Src homology 2 (SH2) domain
    4. XM_030253316.2XP_030109176.1  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2

      Conserved Domains (3) summary
      cd09942
      Location:15123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cl25402
      Location:128288
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
      cl15255
      Location:307352
      SH2; Src homology 2 (SH2) domain
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