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    Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [ Mus musculus (house mouse) ]

    Gene ID: 18707, updated on 11-Apr-2024

    Summary

    Official Symbol
    Pik3cdprovided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit deltaprovided by MGI
    Primary source
    MGI:MGI:1098211
    See related
    Ensembl:ENSMUSG00000039936 AllianceGenome:MGI:1098211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p110delta; 2410099E07Rik; 2610208K16Rik
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in positive regulation of angiogenesis and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including B cell activation; B cell homeostasis; and defense response to fungus. Predicted to be located in cytosol. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in early embryo; hemolymphoid system; nervous system; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; endometrial cancer; and immunodeficiency 14. Orthologous to human PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 42.3), thymus adult (RPKM 28.3) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4 E2; 4 80.15 cM
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149733625..149787023, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149649168..149702566, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene catenin beta interacting protein 1 Neighboring gene predicted gene 13066 Neighboring gene calsyntenin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149032165-149032348 Neighboring gene microRNA 7023 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149063846-149064146 Neighboring gene STARR-positive B cell enhancer ABC_E9249 Neighboring gene STARR-positive B cell enhancer ABC_E2730 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149084694-149084994 Neighboring gene transmembrane protein 201 Neighboring gene solute carrier family 25, member 33 Neighboring gene STARR-seq mESC enhancer starr_12124

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (7)  1 citation
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neutrophil apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Names
    PI3-kinase subunit delta
    PI3K-delta
    PI3Kdelta
    catalytic phosphatidylinositol 3-kinase delta
    p100 delta
    phosphatidylinositol 3-kinase catalytic delta polypeptide
    phosphatidylinositol 3-kinase catalytic subunit delta
    phosphatidylinositol 3-kinase p110 delta
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta
    phosphoinositide 3 kinase P110delta
    ptdIns-3-kinase subunit delta
    ptdIns-3-kinase subunit p110-delta
    NP_001025008.2
    NP_001157521.1
    NP_001157522.1
    NP_001157523.1
    NP_001157524.1
    NP_032866.2
    XP_006538704.1
    XP_006538705.1
    XP_006538706.1
    XP_006538707.1
    XP_006538708.1
    XP_006538709.1
    XP_006538710.1
    XP_006538711.1
    XP_006538712.1
    XP_006538713.1
    XP_006538714.1
    XP_006538715.1
    XP_006538716.1
    XP_017175526.1
    XP_017175527.1
    XP_030109173.1
    XP_030109174.1
    XP_030109175.1
    XP_036019722.1
    XP_036019723.1
    XP_036019724.1
    XP_036019725.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029837.2NP_001025008.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

      See identical proteins and their annotated locations for NP_001025008.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK040867, AK149935, AK153304, AW124359, CF164288
      Consensus CDS
      CCDS51384.1
      UniProtKB/TrEMBL
      Q3T9Y0, Q8BS14
      Related
      ENSMUSP00000136045.2, ENSMUST00000177654.8
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6791045
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    2. NM_001164049.1NP_001157521.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform b

      See identical proteins and their annotated locations for NP_001157521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (b) includes an additional 3-aa internal segment, compared to isoform c. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AL607078, AL626808
      Consensus CDS
      CCDS51384.1
      UniProtKB/TrEMBL
      Q3T9Y0, Q8BS14
      Related
      ENSMUSP00000101315.3, ENSMUST00000105690.9
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6791045
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    3. NM_001164050.1NP_001157522.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform d

      See identical proteins and their annotated locations for NP_001157522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (d) includes an additional 1-aa internal segment, compared to isoform c.
      Source sequence(s)
      AL607078, AL626808
      Consensus CDS
      CCDS51383.1
      UniProtKB/TrEMBL
      B0QZL5, Q546P7, Q8BS14, Q8CI98
      Related
      ENSMUSP00000036434.8, ENSMUST00000038859.14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761043
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    4. NM_001164051.1NP_001157523.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform e

      See identical proteins and their annotated locations for NP_001157523.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, and uses two alternate in-frame splice sites in the central coding region, compared to variant 4. The resulting isoform (e) lacks a 1-aa internal segment and includes an additional 3-aa internal segments, compared to isoform c.
      Source sequence(s)
      AL607078
      Consensus CDS
      CCDS51381.1
      UniProtKB/TrEMBL
      Q3TBW3, Q8BS14
      Related
      ENSMUSP00000112863.2, ENSMUST00000118704.8
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505686
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6781044
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    5. NM_001164052.1NP_001157524.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform a

      See identical proteins and their annotated locations for NP_001157524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the central coding region, compared to variant 4. The promoter and 5' UTR for this variant has not been determined. The resulting isoform (a) lacks a 1-aa internal segment, compared to isoform a.
      Source sequence(s)
      AL607078
      Consensus CDS
      CCDS51380.1
      UniProtKB/Swiss-Prot
      O35904, Q8CJ28
      UniProtKB/TrEMBL
      Q546P7
      Related
      ENSMUSP00000101314.2, ENSMUST00000105689.8
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6751041
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    6. NM_008840.3NP_032866.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform c

      See identical proteins and their annotated locations for NP_032866.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes isoform c.
      Source sequence(s)
      AK040867, AK149935, AK153304, AL626808, AW124359
      Consensus CDS
      CCDS51382.1
      UniProtKB/TrEMBL
      B0QZL5, Q3UDT3, Q546P7, Q8BS14
      Related
      ENSMUSP00000101313.4, ENSMUST00000105688.10
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149733625..149787023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538646.1XP_006538709.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538709.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    2. XM_006538643.2XP_006538706.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538706.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    3. XM_017320037.2XP_017175526.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    4. XM_006538642.5XP_006538705.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538705.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    5. XM_006538648.5XP_006538711.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3

      See identical proteins and their annotated locations for XP_006538711.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505712
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7041071
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    6. XM_006538641.5XP_006538704.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538704.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    7. XM_036163829.1XP_036019722.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    8. XM_030253313.2XP_030109173.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X8

      UniProtKB/TrEMBL
      Q546P7
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6751042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    9. XM_017320038.3XP_017175527.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6791046
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    10. XM_006538650.5XP_006538713.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X6

      See identical proteins and their annotated locations for XP_006538713.1

      UniProtKB/TrEMBL
      B0QZL5, Q546P7, Q8BS14, Q8CI98
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761043
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    11. XM_006538644.5XP_006538707.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538707.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    12. XM_006538645.1XP_006538708.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1

      See identical proteins and their annotated locations for XP_006538708.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051072
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    13. XM_006538653.2XP_006538716.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X10

      See identical proteins and their annotated locations for XP_006538716.1

      Conserved Domains (3) summary
      cd08693
      Location:79219
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:242451
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:443810
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    14. XM_036163832.1XP_036019725.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X13

      Conserved Domains (3) summary
      cd08693
      Location:79219
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:243421
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:413780
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    15. XM_030253314.2XP_030109174.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X11

      Conserved Domains (3) summary
      cd08693
      Location:79219
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:242422
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:414781
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    16. XM_036163830.1XP_036019723.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

      UniProtKB/TrEMBL
      B0QZL5, Q3UDT3, Q546P7, Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    17. XM_006538647.5XP_006538710.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2

      See identical proteins and their annotated locations for XP_006538710.1

      UniProtKB/TrEMBL
      Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504713
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:7051071
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    18. XM_006538652.5XP_006538715.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X9

      See identical proteins and their annotated locations for XP_006538715.1

      UniProtKB/Swiss-Prot
      O35904, Q8CJ28
      UniProtKB/TrEMBL
      Q546P7
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:505683
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6751041
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    19. XM_006538651.4XP_006538714.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X7

      See identical proteins and their annotated locations for XP_006538714.1

      UniProtKB/TrEMBL
      B0QZL5, Q3UDT3, Q546P7, Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504684
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6761042
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    20. XM_006538649.4XP_006538712.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X5

      See identical proteins and their annotated locations for XP_006538712.1

      UniProtKB/TrEMBL
      Q3T9Y0, Q8BS14
      Conserved Domains (5) summary
      cd08693
      Location:314481
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:504687
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:6791045
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
      pfam00794
      Location:182281
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain
    21. XM_030253315.2XP_030109175.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X14

      Conserved Domains (3) summary
      cd08693
      Location:79219
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:243421
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:413779
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta
    22. XM_036163831.1XP_036019724.1  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X12

      Conserved Domains (3) summary
      cd08693
      Location:79219
      C2_PI3K_class_I_beta_delta; C2 domain present in class I beta and delta phosphatidylinositol 3-kinases (PI3Ks)
      smart00145
      Location:242422
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain)
      cd05174
      Location:414780
      PI3Kc_IA_delta; Catalytic domain of Class IA Phosphoinositide 3-kinase delta