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    Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [ Mus musculus (house mouse) ]

    Gene ID: 18706, updated on 14-Sep-2021

    Summary

    Official Symbol
    Pik3caprovided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaprovided by MGI
    Primary source
    MGI:MGI:1206581
    See related
    Ensembl:ENSMUSG00000027665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    caP; p110; caPI3K; p110alpha; 6330412C24Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 6.2), cerebellum adult (RPKM 5.7) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pik3ca in Genome Data Viewer
    Location:
    3 A3; 3 15.7 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32451203..32520256)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32397065..32466112)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (32335073..32367408)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930429B21 gene Neighboring gene zinc finger matrin type 3 Neighboring gene predicted gene, 54172 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene guanine nucleotide binding protein (G protein), beta 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC161268

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrostatic pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hypomethylation of CpG island IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of actin filament depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cellular respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of genetic imprinting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in relaxation of cardiac muscle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class IB IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Names
    PI3-kinase subunit alpha
    PI3K-alpha
    PI3Kalpha
    phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
    phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
    phosphoinositide-3-kinase catalytic alpha polypeptide
    ptdIns-3-kinase subunit alpha
    ptdIns-3-kinase subunit p110-alpha
    serine/threonine protein kinase PIK3CA
    NP_032865.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008839.3NP_032865.2  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

      See identical proteins and their annotated locations for NP_032865.2

      Status: VALIDATED

      Source sequence(s)
      AC110034, AC130281
      Consensus CDS
      CCDS38409.1
      UniProtKB/Swiss-Prot
      P42337
      Related
      ENSMUSP00000103878.2, ENSMUST00000108243.8
      Conserved Domains (5) summary
      cd08398
      Location:325484
      C2_PI3K_class_I_alpha; C2 domain present in class I alpha phosphatidylinositol 3-kinases (PI3Ks)
      cd00872
      Location:525696
      PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...
      cd05175
      Location:6951064
      PI3Kc_IA_alpha; Catalytic domain of Class IA Phosphoinositide 3-kinase alpha
      pfam00794
      Location:173292
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam02192
      Location:32107
      PI3K_p85B; PI3-kinase family, p85-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      32451203..32520256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004941295.1 RNA Sequence

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