Format

Send to:

Choose Destination
    • Showing Current items.

    Pik3c2a phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [ Mus musculus (house mouse) ]

    Gene ID: 18704, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pik3c2aprovided by MGI
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alphaprovided by MGI
    Primary source
    MGI:MGI:1203729
    See related
    Ensembl:ENSMUSG00000030660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI3K; Cpk-m; PI3KC2
    Expression
    Ubiquitous expression in placenta adult (RPKM 5.5), limb E14.5 (RPKM 4.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pik3c2a in Genome Data Viewer
    Location:
    7 F1; 7 61.62 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (115936500..116042693, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (116337265..116443465, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (123480790..123586972, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 7 Neighboring gene predicted gene 44867 Neighboring gene small nucleolar RNA, C/D box 14A Neighboring gene predicted gene 10589 Neighboring gene ribosomal protein S13 Neighboring gene predicted gene, 40453 Neighboring gene predicted gene, 32676 Neighboring gene nucleobindin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-3,4-bisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagosome organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within macroautophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of zinc ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
    Names
    PI3K-C2-alpha
    p170
    phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
    phosphoinositide 3-kinase-C2-alpha
    ptdIns-3-kinase C2 subunit alpha
    NP_035213.2
    XP_006507503.1
    XP_006507504.1
    XP_030098074.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011083.2NP_035213.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

      See identical proteins and their annotated locations for NP_035213.2

      Status: VALIDATED

      Source sequence(s)
      AC104918, AK136732, BC096553, BY014484, BY034035, BY726923, U55772
      Consensus CDS
      CCDS52371.1
      UniProtKB/Swiss-Prot
      Q61194
      UniProtKB/TrEMBL
      F8VPL2
      Related
      ENSMUSP00000126092.2, ENSMUST00000170430.3
      Conserved Domains (7) summary
      cd07289
      Location:14261534
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:677849
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15601681
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:8691038
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05176
      Location:10431395
      PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
      pfam00794
      Location:421513
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam04621
      Location:40210
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      115936500..116042693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507440.5XP_006507503.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_006507503.1

      UniProtKB/TrEMBL
      F8VPL2
      Related
      ENSMUSP00000146181.2, ENSMUST00000206219.2
      Conserved Domains (7) summary
      cd07289
      Location:14261534
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:677849
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:15601681
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:8691038
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05176
      Location:10431395
      PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
      pfam00794
      Location:421513
      PI3K_rbd; PI3-kinase family, ras-binding domain
      pfam04621
      Location:40210
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    2. XM_006507441.5XP_006507504.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

      See identical proteins and their annotated locations for XP_006507504.1

      Conserved Domains (6) summary
      cd07289
      Location:10091117
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:260432
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:11431264
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:452621
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05176
      Location:626978
      PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
      pfam00794
      Location:496
      PI3K_rbd; PI3-kinase family, ras-binding domain
    3. XM_030242214.2XP_030098074.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

      Conserved Domains (6) summary
      cd07289
      Location:10091117
      PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:260432
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:11431264
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:452621
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cd05176
      Location:626978
      PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
      pfam00794
      Location:496
      PI3K_rbd; PI3-kinase family, ras-binding domain
    Support Center