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    Piga phosphatidylinositol glycan anchor biosynthesis, class A [ Mus musculus (house mouse) ]

    Gene ID: 18700, updated on 26-Aug-2018

    Summary

    Official Symbol
    Pigaprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Aprovided by MGI
    Primary source
    MGI:MGI:99461
    See related
    Ensembl:ENSMUSG00000031381 Vega:OTTMUSG00000019508
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pig-a; AI194334
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 4.8), liver E14 (RPKM 4.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Piga in Genome Data Viewer
    Location:
    X F5; X 76.49 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (164419685..164433916)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (160857719..160871847)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene pirin Neighboring gene vascular endothelial growth factor D Neighboring gene ankyrin repeat and SOCS box-containing 11 Neighboring gene chromobox protein homolog 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phosphatidylinositol N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
    Names
    glcNAc-PI synthesis protein
    phosphatidylinositol glycan, class A
    phosphatidylinositol-glycan biosynthesis class A protein
    phosphatidylinositolglycan class A
    NP_035211.2
    XP_006528821.1
    XP_011246095.1
    XP_017173917.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011081.3NP_035211.2  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein

      See identical proteins and their annotated locations for NP_035211.2

      Status: VALIDATED

      Source sequence(s)
      AK032283, AL732475
      Consensus CDS
      CCDS30522.1
      UniProtKB/Swiss-Prot
      Q64323
      UniProtKB/TrEMBL
      A2AIH5
      Related
      ENSMUSP00000033754.7, OTTMUSP00000021037, ENSMUST00000033754.14
      Conserved Domains (2) summary
      cd03796
      Location:34433
      GT1_PIG-A_like; This family is most closely related to the GT1 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate ...
      COG0438
      Location:34405
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

    RNA

    1. NR_152315.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL732475

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      164419685..164433916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528758.3XP_006528821.1  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein isoform X3

      UniProtKB/TrEMBL
      Q3TB52
      Conserved Domains (2) summary
      COG0438
      Location:189
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cl10013
      Location:1117
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
    2. XM_017318428.1XP_017173917.1  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein isoform X1

      UniProtKB/Swiss-Prot
      Q64323
      UniProtKB/TrEMBL
      A2AIH5
      Related
      ENSMUSP00000107874.1, OTTMUSP00000021039, ENSMUST00000112255.7, OTTMUST00000046590
      Conserved Domains (2) summary
      cd03796
      Location:34433
      GT1_PIG-A_like; This family is most closely related to the GT1 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate ...
      COG0438
      Location:34405
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    3. XM_011247793.2XP_011246095.1  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein isoform X2

      Related
      ENSMUSP00000146731.1, OTTMUSP00000075504, ENSMUST00000208697.1, OTTMUST00000144922
      Conserved Domains (2) summary
      COG0438
      Location:9180
      RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cl10013
      Location:13208
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
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