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    Pgk1 phosphoglycerate kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18655, updated on 24-Apr-2022

    Summary

    Official Symbol
    Pgk1provided by MGI
    Official Full Name
    phosphoglycerate kinase 1provided by MGI
    Primary source
    MGI:MGI:97555
    See related
    Ensembl:ENSMUSG00000062070 AllianceGenome:MGI:97555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgk-1
    Summary
    The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in placenta adult (RPKM 206.0), liver E18 (RPKM 170.7) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pgk1 in Genome Data Viewer
    Location:
    X D; X 47.36 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105230706..105247305)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106187100..106203699)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (103382463..103399038)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene toll-like receptor 13 Neighboring gene TM2 domain containing 2 pseudogene Neighboring gene TATA-box binding protein associated factor 9B Neighboring gene fibronectin type III domain containing 3C2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118097

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoglycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphoglycerate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphoglycerate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-disulfide reductase (NAD(P)) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in canonical glycolysis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in gluconeogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphoglycerate kinase 1
    NP_032854.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008828.3NP_032854.2  phosphoglycerate kinase 1

      See identical proteins and their annotated locations for NP_032854.2

      Status: REVIEWED

      Source sequence(s)
      AK133877, BE986846, BY292706
      Consensus CDS
      CCDS30339.1
      UniProtKB/Swiss-Prot
      P09411
      Related
      ENSMUSP00000080302.7, ENSMUST00000081593.13
      Conserved Domains (1) summary
      PTZ00005
      Location:3416
      PTZ00005; phosphoglycerate kinase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105230706..105247305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)