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    Pemt phosphatidylethanolamine N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 18618, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pemtprovided by MGI
    Official Full Name
    phosphatidylethanolamine N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:104535
    See related
    Ensembl:ENSMUSG00000000301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pem; PLMT; Pemp; PEAMT; PEMT2; Pempt; D9Mgi2; Pempt2
    Expression
    Biased expression in liver adult (RPKM 380.3), liver E18 (RPKM 210.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Pemt in Genome Data Viewer
    Location:
    11 B1.3; 11 37.81 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59861440..59937394, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59970614..60046561, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (59784119..59850341, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 9, opposite strand Neighboring gene mediator complex subunit 9 Neighboring gene RAS, dexamethasone-induced 1 Neighboring gene predicted gene, 53709 Neighboring gene predicted gene, 38498 Neighboring gene RIKEN cDNA 4930412M03 gene Neighboring gene retinoic acid induced 1 Neighboring gene predicted gene, 53710

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphatidylcholine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sphingomyelin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial envelope TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylethanolamine N-methyltransferase
    Names
    phospholipid methyltransferase
    NP_001276940.1
    NP_001276941.1
    NP_001276942.1
    NP_001276943.1
    NP_032845.2
    XP_006532541.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290011.1NP_001276940.1  phosphatidylethanolamine N-methyltransferase isoform a

      See identical proteins and their annotated locations for NP_001276940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AA245746, AK133744, BY251884
      Consensus CDS
      CCDS78957.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000099754.3, ENSMUST00000102693.9
      Conserved Domains (1) summary
      pfam04191
      Location:126228
      PEMT; Phospholipid methyltransferase
    2. NM_001290012.1NP_001276941.1  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_001276941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, AL645526, BY251884, CJ048474
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000000310.8, ENSMUST00000000310.14
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase
    3. NM_001290013.1NP_001276942.1  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_001276942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, BG084478, CN708035
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase
    4. NM_001290014.1NP_001276943.1  phosphatidylethanolamine N-methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It also lacks two in-frame exons compared to variant 1. It encodes isoform c which is shorter than isoform a.
      Source sequence(s)
      AA245746, AK133744, BG084478, CN708035
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000116314.2, ENSMUST00000147422.8
      Conserved Domains (1) summary
      cl21511
      Location:70105
      PEMT; Phospholipid methyltransferase
    5. NM_008819.3NP_032845.2  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_032845.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, AL645526, AY334571
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000099753.4, ENSMUST00000102692.10
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59861440..59937394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532478.5XP_006532541.1  phosphatidylethanolamine N-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam04191
      Location:115217
      PEMT; Phospholipid methyltransferase
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