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    Pemt phosphatidylethanolamine N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 18618, updated on 23-Oct-2018

    Summary

    Official Symbol
    Pemtprovided by MGI
    Official Full Name
    phosphatidylethanolamine N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:104535
    See related
    Ensembl:ENSMUSG00000000301 Vega:OTTMUSG00000005808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PLMT; PEAMT; PEMT2; Pempt; Pempt2
    Expression
    Biased expression in liver adult (RPKM 380.3), liver E18 (RPKM 210.1) and 1 other tissue See more
    Orthologs

    Genomic context

    See Pemt in Genome Data Viewer
    Location:
    11 B1.3; 11 37.81 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (59970614..60046510, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (59784119..59850341, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 9, opposite strand Neighboring gene mediator complex subunit 9 Neighboring gene RAS, dexamethasone-induced 1 Neighboring gene predicted gene, 38498 Neighboring gene retinoic acid induced 1 Neighboring gene microRNA 6921 Neighboring gene sterol regulatory element binding transcription factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    S-adenosylmethionine-dependent methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidyl-N-dimethylethanolamine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidyl-N-methylethanolamine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylethanolamine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylethanolamine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylethanolamine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    S-adenosylhomocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glycerophospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylcholine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipoprotein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to vitamin ISO
    Inferred from Sequence Orthology
    more info
     
    sphingomyelin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial envelope TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrion HDA PubMed 
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphatidylethanolamine N-methyltransferase
    Names
    phospholipid methyltransferase
    NP_001276940.1
    NP_001276941.1
    NP_001276942.1
    NP_001276943.1
    NP_032845.2
    XP_006532541.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290011.1NP_001276940.1  phosphatidylethanolamine N-methyltransferase isoform a

      See identical proteins and their annotated locations for NP_001276940.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AA245746, AK133744, BY251884
      Consensus CDS
      CCDS78957.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000099754.2, OTTMUSP00000005980, ENSMUST00000102693.8, OTTMUST00000012858
      Conserved Domains (1) summary
      pfam04191
      Location:126228
      PEMT; Phospholipid methyltransferase
    2. NM_001290012.1NP_001276941.1  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_001276941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in its 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, AL645526, BY251884, CJ048474
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000000310.7, OTTMUSP00000005983, ENSMUST00000000310.13, OTTMUST00000012861
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase
    3. NM_001290013.1NP_001276942.1  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_001276942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, BG084478, CN708035
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase
    4. NM_001290014.1NP_001276943.1  phosphatidylethanolamine N-methyltransferase isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It also lacks two in-frame exons compared to variant 1. It encodes isoform c which is shorter than isoform a.
      Source sequence(s)
      AA245746, AK133744, BG084478, CN708035
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000116314.1, OTTMUSP00000005984, ENSMUST00000147422.7, OTTMUST00000012862
      Conserved Domains (1) summary
      cl21511
      Location:70105
      PEMT; Phospholipid methyltransferase
    5. NM_008819.3NP_032845.2  phosphatidylethanolamine N-methyltransferase isoform b

      See identical proteins and their annotated locations for NP_032845.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 2, 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AA245746, AK133744, AL645526, AY334571
      Consensus CDS
      CCDS24782.1
      UniProtKB/Swiss-Prot
      Q61907
      Related
      ENSMUSP00000099753.3, OTTMUSP00000005981, ENSMUST00000102692.9, OTTMUST00000012859
      Conserved Domains (1) summary
      pfam04191
      Location:89191
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      59970614..60046510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532478.3XP_006532541.1  phosphatidylethanolamine N-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam04191
      Location:115217
      PEMT; Phospholipid methyltransferase
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