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    Pde8a phosphodiesterase 8A [ Mus musculus (house mouse) ]

    Gene ID: 18584, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pde8aprovided by MGI
    Official Full Name
    phosphodiesterase 8Aprovided by MGI
    Primary source
    MGI:MGI:1277116
    See related
    Ensembl:ENSMUSG00000025584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pde; Pde8; AI551852
    Expression
    Broad expression in testis adult (RPKM 48.2), kidney adult (RPKM 13.7) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Pde8a in Genome Data Viewer
    Location:
    7; 7 D3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80863013..80984283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81213265..81334535)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (88358690..88478508)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6B Neighboring gene predicted gene 44968 Neighboring gene translocase of inner mitochondrial membrane 17a pseudogene Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
    NP_032829.1
    XP_036008663.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008803.3NP_032829.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

      See identical proteins and their annotated locations for NP_032829.1

      Status: VALIDATED

      Source sequence(s)
      AF067806, AK148238, AV272936, BC125578, CO808457
      Consensus CDS
      CCDS40005.1
      UniProtKB/Swiss-Prot
      O88502
      Related
      ENSMUSP00000026672.8, ENSMUST00000026672.8
      Conserved Domains (5) summary
      COG0745
      Location:78155
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
      cd00130
      Location:226320
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam00233
      Location:550801
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam13426
      Location:222320
      PAS_9; PAS domain
      cl19078
      Location:79165
      REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80863013..80984283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152770.1XP_036008663.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

      Conserved Domains (4) summary
      COG0745
      Location:78155
      OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
      COG2202
      Location:118320
      PAS; PAS domain [Signal transduction mechanisms]
      pfam13426
      Location:222320
      PAS_9; PAS domain
      cl21469
      Location:550574
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
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