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    Pde6d phosphodiesterase 6D, cGMP-specific, rod, delta [ Mus musculus (house mouse) ]

    Gene ID: 18582, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pde6dprovided by MGI
    Official Full Name
    phosphodiesterase 6D, cGMP-specific, rod, deltaprovided by MGI
    Primary source
    MGI:MGI:1270843
    See related
    Ensembl:ENSMUSG00000026239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI841218; PrBP/delta
    Expression
    Ubiquitous expression in CNS E18 (RPKM 26.2), testis adult (RPKM 22.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pde6d in Genome Data Viewer
    Location:
    1; 1 C5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (86470734..86510507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (86543012..86582785, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (88439590..88479076, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30, pseudogene 6 Neighboring gene prothymosin alpha Neighboring gene COP9 signalosome subunit 7B Neighboring gene predicted gene, 41908 Neighboring gene natriuretic peptide type C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Chemically induced (ENU) (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cyclic-GMP phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within phototransduction TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
    Names
    GMP-PDE delta
    NP_001347745.1
    NP_001347746.1
    NP_032827.1
    XP_030108092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360816.1NP_001347745.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC158132, AK141209, BU919914
      Conserved Domains (1) summary
      pfam05351
      Location:1088
      GMP_PDE_delta; GMP-PDE, delta subunit
    2. NM_001360817.1NP_001347746.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC158132, AK141209, AK165701
      Conserved Domains (1) summary
      pfam05351
      Location:179
      GMP_PDE_delta; GMP-PDE, delta subunit
    3. NM_008801.3NP_032827.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform 1

      See identical proteins and their annotated locations for NP_032827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC158132, AK141209
      Consensus CDS
      CCDS15121.1
      UniProtKB/Swiss-Prot
      O55057
      UniProtKB/TrEMBL
      Q3TDQ8
      Related
      ENSMUSP00000027444.9, ENSMUST00000027444.15
      Conserved Domains (1) summary
      pfam05351
      Location:10149
      GMP_PDE_delta; GMP-PDE, delta subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      86470734..86510507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252232.1XP_030108092.1  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1

      Conserved Domains (1) summary
      pfam05351
      Location:179
      GMP_PDE_delta; GMP-PDE, delta subunit
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