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    Pde3b phosphodiesterase 3B, cGMP-inhibited [ Mus musculus (house mouse) ]

    Gene ID: 18576, updated on 18-Sep-2024

    Summary

    Official Symbol
    Pde3bprovided by MGI
    Official Full Name
    phosphodiesterase 3B, cGMP-inhibitedprovided by MGI
    Primary source
    MGI:MGI:1333863
    See related
    Ensembl:ENSMUSG00000030671 AllianceGenome:MGI:1333863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830102A01Rik
    Summary
    Enables protein kinase B binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose homeostasis; and regulation of insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 10.0), adrenal adult (RPKM 8.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Pde3b in Genome Data Viewer
    Location:
    7 F1; 7 59.46 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114014388..114137173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114415222..114537938)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene STARR-positive B cell enhancer ABC_E9299 Neighboring gene STARR-positive B cell enhancer ABC_E10466 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121444899-121445200 Neighboring gene proteasome subunit alpha 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121461019-121461282 Neighboring gene STARR-positive B cell enhancer ABC_E11365 Neighboring gene STARR-seq mESC enhancer starr_19927 Neighboring gene STARR-positive B cell enhancer ABC_E3745 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene STARR-seq mESC enhancer starr_19930 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_19932 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within endocrine pancreas development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
    Names
    CGI-PDE B
    CGIPDE1
    cGMP-inhibited 3',5'-cyclic phosphodiesterase B
    cyclic GMP-inhibited phosphodiesterase B
    NP_035185.2
    XP_006507501.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011055.2NP_035185.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

      Status: VALIDATED

      Source sequence(s)
      AJ132271, AK142889, AV270888, BB627812, BB663310, BU613166, BY745829, CJ058099, CJ299201
      Consensus CDS
      CCDS21760.1
      UniProtKB/Swiss-Prot
      Q61409, Q8CIX5, Q9Z1J9
      UniProtKB/TrEMBL
      E9QLQ3
      Related
      ENSMUSP00000032909.9, ENSMUST00000032909.9
      Conserved Domains (2) summary
      pfam00233
      Location:712986
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam06532
      Location:60241
      DUF1109; Protein of unknown function (DUF1109)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      114014388..114137173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507438.5XP_006507501.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1

      UniProtKB/Swiss-Prot
      Q61409, Q8CIX5, Q9Z1J9
      Conserved Domains (2) summary
      pfam00233
      Location:695969
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam10101
      Location:116260
      DUF2339; Predicted membrane protein (DUF2339)

    RNA

    1. XR_001785490.3 RNA Sequence

    2. XR_003946416.2 RNA Sequence