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    Pde3b phosphodiesterase 3B, cGMP-inhibited [ Mus musculus (house mouse) ]

    Gene ID: 18576, updated on 21-Oct-2018

    Summary

    Official Symbol
    Pde3bprovided by MGI
    Official Full Name
    phosphodiesterase 3B, cGMP-inhibitedprovided by MGI
    Primary source
    MGI:MGI:1333863
    See related
    Ensembl:ENSMUSG00000030671 Vega:OTTMUSG00000025593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI847709; 9830102A01Rik
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 10.0), adrenal adult (RPKM 8.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Pde3b in Genome Data Viewer
    Location:
    7 F1; 7 59.46 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (114411891..114537942)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (121558768..121681451)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 1 Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    3',5'-cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase B binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    endocrine pancreas development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cGMP-inhibited 3',5'-cyclic phosphodiesterase B
    Names
    CGI-PDE B
    CGIPDE1
    cyclic GMP-inhibited phosphodiesterase B
    NP_035185.2
    XP_006507501.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011055.2NP_035185.2  cGMP-inhibited 3',5'-cyclic phosphodiesterase B

      Status: VALIDATED

      Source sequence(s)
      AJ132271, AK142889, AV270888, BB627812, BB663310, BU613166, BY745829, CJ058099, CJ299201
      Consensus CDS
      CCDS21760.1
      UniProtKB/Swiss-Prot
      Q61409
      UniProtKB/TrEMBL
      E9QLQ3, Q3UQ25
      Related
      ENSMUSP00000032909.8, OTTMUSP00000031097, ENSMUST00000032909.8, OTTMUST00000062959
      Conserved Domains (2) summary
      pfam00233
      Location:712986
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam06532
      Location:60241
      DUF1109; Protein of unknown function (DUF1109)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      114411891..114537942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507438.3XP_006507501.1  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1

      Conserved Domains (2) summary
      pfam00233
      Location:695969
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam06532
      Location:60241
      DUF1109; Protein of unknown function (DUF1109)

    RNA

    1. XR_001785489.1 RNA Sequence

    2. XR_001785490.1 RNA Sequence

    3. XR_001785491.1 RNA Sequence

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