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    Pdcd6ip programmed cell death 6 interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 18571, updated on 11-Nov-2018

    Summary

    Official Symbol
    Pdcd6ipprovided by MGI
    Official Full Name
    programmed cell death 6 interacting proteinprovided by MGI
    Primary source
    MGI:MGI:1333753
    See related
    Ensembl:ENSMUSG00000032504 Vega:OTTMUSG00000026168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aip1; Alix; Eig2; C76364; AI480591; AW544830; mKIAA1375
    Expression
    Ubiquitous expression in adrenal adult (RPKM 72.0), colon adult (RPKM 53.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pdcd6ip in Genome Data Viewer
    Location:
    9; 9 F3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (113651744..113708259, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (113560862..113617377, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36686 Neighboring gene predicted gene, 36745 Neighboring gene predicted gene, 38623 Neighboring gene CLIP associating protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
      PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    proteinase activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbody abscission ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
     
    viral budding ISO
    Inferred from Sequence Orthology
    more info
     
    viral budding via host ESCRT complex ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Flemming body ISO
    Inferred from Sequence Orthology
    more info
     
    actomyosin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    immunological synapse ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    programmed cell death 6-interacting protein
    Names
    ALG-2-interacting protein 1
    ALG-2-interacting protein X
    Alg2-interacting protein 1
    Alg2-interacting protein X
    E2f1-inducible protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164677.1NP_001158149.1  programmed cell death 6-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_001158149.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC167246, AK029827, AK031256, AK157704, AK167574, BE623112, BM899382
      Consensus CDS
      CCDS52947.1
      UniProtKB/Swiss-Prot
      Q9WU78
      Related
      ENSMUSP00000107492.3, OTTMUSP00000032131, ENSMUST00000111861.3, OTTMUST00000064649
      Conserved Domains (4) summary
      cd09235
      Location:365703
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:2350
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam12273
      Location:821874
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam13949
      Location:417706
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
    2. NM_001164678.1NP_001158150.1  programmed cell death 6-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001158150.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC167246, AK029827, AK157704, AK167574, BE623112, BM899382, CX210461
      UniProtKB/Swiss-Prot
      Q9WU78
      UniProtKB/TrEMBL
      Q80Y09
      Conserved Domains (4) summary
      cd09235
      Location:360698
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:2345
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam12273
      Location:819872
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam13949
      Location:412701
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
    3. NM_011052.2NP_035182.2  programmed cell death 6-interacting protein isoform 3

      See identical proteins and their annotated locations for NP_035182.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC167246, AK029827, AK157704, AK167574, BE623112, BM899382
      Consensus CDS
      CCDS23588.1
      UniProtKB/Swiss-Prot
      Q9WU78
      Related
      ENSMUSP00000035086.6, OTTMUSP00000032130, ENSMUST00000035086.12, OTTMUST00000064648
      Conserved Domains (4) summary
      cd09235
      Location:360698
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:2345
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam12273
      Location:816869
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam13949
      Location:412701
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      113651744..113708259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242941.2XP_011241243.1  programmed cell death 6-interacting protein isoform X1

      Conserved Domains (4) summary
      cd09235
      Location:365703
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:2350
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam12273
      Location:824877
      RCR; Chitin synthesis regulation, resistance to Congo red
      pfam13949
      Location:417706
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV
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