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    Pdcd4 programmed cell death 4 [ Mus musculus (house mouse) ]

    Gene ID: 18569, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pdcd4provided by MGI
    Official Full Name
    programmed cell death 4provided by MGI
    Primary source
    MGI:MGI:107490
    See related
    Ensembl:ENSMUSG00000024975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T; MA-; Ma3; Tis; D19Ucl; D19Ucla1
    Expression
    Broad expression in bladder adult (RPKM 26.5), placenta adult (RPKM 14.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pdcd4 in Genome Data Viewer
    Location:
    19 D2; 19 48.73 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53880662..53926024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53892231..53937592)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (53966721..54004351)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene, 30890 Neighboring gene predicted gene 16299 Neighboring gene predicted gene, 30990 Neighboring gene BBSome interacting protein 1 Neighboring gene Shoc2, leucine rich repeat scaffold protein Neighboring gene adrenergic receptor, alpha 2a

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of myofibroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NIK/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    programmed cell death protein 4
    Names
    protein MA-3
    topoisomerase-inhibitor suppressed protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168491.1NP_001161963.1  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_001161963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000025931.7, ENSMUST00000025931.14
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    2. NM_001168492.1NP_001161964.1  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_001161964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612, BC055739
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000133135.2, ENSMUST00000165617.3
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    3. NM_011050.4NP_035180.2  programmed cell death protein 4

      See identical proteins and their annotated locations for NP_035180.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC117612, AK134366
      Consensus CDS
      CCDS29903.1
      UniProtKB/Swiss-Prot
      Q61823
      Related
      ENSMUSP00000073975.6, ENSMUST00000074371.13
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      53880662..53926024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250768.2XP_030106628.1  programmed cell death protein 4 isoform X1

      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    2. XM_036161459.1XP_036017352.1  programmed cell death protein 4 isoform X1

      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    3. XM_006526762.5XP_006526825.1  programmed cell death protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006526825.1

      UniProtKB/Swiss-Prot
      Q61823
      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    4. XM_036161461.1XP_036017354.1  programmed cell death protein 4 isoform X1

      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    5. XM_030250769.1XP_030106629.1  programmed cell death protein 4 isoform X1

      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    6. XM_036161460.1XP_036017353.1  programmed cell death protein 4 isoform X1

      Conserved Domains (1) summary
      smart00544
      Location:327440
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
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