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    Cdk16 cyclin-dependent kinase 16 [ Mus musculus (house mouse) ]

    Gene ID: 18555, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdk16provided by MGI
    Official Full Name
    cyclin-dependent kinase 16provided by MGI
    Primary source
    MGI:MGI:97516
    See related
    Ensembl:ENSMUSG00000031065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk5; Pctk1; Pctaire1
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 104.3), adrenal adult (RPKM 90.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdk16 in Genome Data Viewer
    Location:
    X A1.3; X 16.18 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (20687954..20699880)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (20265619..20277003)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene predicted gene, 39499 Neighboring gene predicted gene, 39500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 16
    Names
    PCTAIRE-motif protein kinase 1
    cell division protein kinase 16
    serine/threonine-protein kinase PCTAIRE-1
    NP_001297385.1
    NP_035179.1
    XP_006527633.1
    XP_017173913.1
    XP_017173914.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310456.1NP_001297385.1  cyclin-dependent kinase 16 isoform 2

      See identical proteins and their annotated locations for NP_001297385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      BY245451, X69025
      Consensus CDS
      CCDS81103.1
      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      Q3TM24
      Related
      ENSMUSP00000111021.1, ENSMUST00000115364.7
      Conserved Domains (2) summary
      PLN00009
      Location:127415
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:127423
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. NM_011049.5NP_035179.1  cyclin-dependent kinase 16 isoform 1

      See identical proteins and their annotated locations for NP_035179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AA241790, AK145483, CX242782
      Consensus CDS
      CCDS30045.1
      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      Q543G3
      Related
      ENSMUSP00000033380.6, ENSMUST00000033380.6
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      20687954..20699880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527570.1XP_006527633.1  cyclin-dependent kinase 16 isoform X2

      See identical proteins and their annotated locations for XP_006527633.1

      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      Q543G3
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. XM_017318425.1XP_017173914.1  cyclin-dependent kinase 16 isoform X3

      UniProtKB/TrEMBL
      Q3TM24
      Conserved Domains (2) summary
      PLN00009
      Location:127415
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:127423
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    3. XM_017318424.1XP_017173913.1  cyclin-dependent kinase 16 isoform X1

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