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    Cdk16 cyclin-dependent kinase 16 [ Mus musculus (house mouse) ]

    Gene ID: 18555, updated on 22-Sep-2022

    Summary

    Official Symbol
    Cdk16provided by MGI
    Official Full Name
    cyclin-dependent kinase 16provided by MGI
    Primary source
    MGI:MGI:97516
    See related
    Ensembl:ENSMUSG00000031065 AllianceGenome:MGI:97516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk5; Pctk1; Pctaire1
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including regulation of insulin secretion involved in cellular response to glucose stimulus; secretion by cell; and spermatogenesis. Colocalizes with synaptic vesicle. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 104.3), adrenal adult (RPKM 90.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cdk16 in Genome Data Viewer
    Location:
    X A1.3; X 16.18 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20554156..20566119)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20687917..20699880)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (20265619..20277003)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit B11 Neighboring gene RNA binding motif protein 10 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene predicted gene, 39499 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene predicted gene, 39500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in growth hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 16
    Names
    PCTAIRE-motif protein kinase 1
    cell division protein kinase 16
    serine/threonine-protein kinase PCTAIRE-1
    NP_001297385.1
    NP_035179.1
    XP_006527633.1
    XP_017173914.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310456.2NP_001297385.1  cyclin-dependent kinase 16 isoform 2

      See identical proteins and their annotated locations for NP_001297385.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 4 encode the same protein (isoform 2), which has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL807240
      Consensus CDS
      CCDS81103.1
      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      Q3TM24
      Related
      ENSMUSP00000111021.2, ENSMUST00000115364.8
      Conserved Domains (1) summary
      cd07873
      Location:127423
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. NM_001411705.1NP_001398634.1  cyclin-dependent kinase 16 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL807240
    3. NM_001411707.1NP_001398636.1  cyclin-dependent kinase 16 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL807240
    4. NM_011049.6NP_035179.1  cyclin-dependent kinase 16 isoform 1

      See identical proteins and their annotated locations for NP_035179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AL807240
      Consensus CDS
      CCDS30045.1
      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      A0A6P5NXX0, Q543G3
      Related
      ENSMUSP00000033380.7, ENSMUST00000033380.7
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20554156..20566119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527570.2XP_006527633.1  cyclin-dependent kinase 16 isoform X1

      UniProtKB/Swiss-Prot
      Q04735
      UniProtKB/TrEMBL
      A0A6P5NXX0, Q543G3
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. XM_017318425.2XP_017173914.1  cyclin-dependent kinase 16 isoform X2

      UniProtKB/TrEMBL
      Q3TM24
      Conserved Domains (1) summary
      cd07873
      Location:127423
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase