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    Furin furin (paired basic amino acid cleaving enzyme) [ Mus musculus (house mouse) ]

    Gene ID: 18550, updated on 19-Jul-2021

    Summary

    Official Symbol
    Furinprovided by MGI
    Official Full Name
    furin (paired basic amino acid cleaving enzyme)provided by MGI
    Primary source
    MGI:MGI:97513
    See related
    Ensembl:ENSMUSG00000030530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fu; PA; SP; Fur; Pcs; PACE; SPC1; Pcsk3; 9130404I01Rik
    Summary
    This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
    Expression
    Broad expression in stomach adult (RPKM 243.5), adrenal adult (RPKM 89.1) and 15 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Furin in Genome Data Viewer
    Location:
    7 D2; 7 45.65 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80038942..80055188, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80389194..80405441, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87534080..87550317, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mannosidase 2, alpha 2 Neighboring gene feline sarcoma oncogene Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene Neighboring gene VISTA enhancer mm169

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blastocyst formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dibasic protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of low-density lipoprotein particle receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta1 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nerve growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta1 activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in secretion by cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal peptide processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen inhibition ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in integral component of Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in trans-Golgi network transport vesicle membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    furin
    Names
    dibasic-processing enzyme
    paired basic amino acid residue cleaving enzyme
    prohormone convertase 3
    proprotein convertase subtilisin/kexin type 3
    subtilisin pro-protein processing enzyme
    NP_001074923.1
    NP_035176.1
    XP_011249120.1
    XP_011249121.1
    XP_011249122.1
    XP_011249123.1
    XP_011249124.1
    XP_011249125.1
    XP_030098069.1
    XP_030098070.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081454.2NP_001074923.1  furin preproprotein

      See identical proteins and their annotated locations for NP_001074923.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC136740
      Consensus CDS
      CCDS21397.1
      UniProtKB/Swiss-Prot
      P23188
      Related
      ENSMUSP00000102985.4, ENSMUST00000107362.10
      Conserved Domains (4) summary
      cd04059
      Location:113402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638675
      FU; Furin-like repeats
      pfam01483
      Location:484570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    2. NM_011046.3NP_035176.1  furin preproprotein

      See identical proteins and their annotated locations for NP_035176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC136740
      Consensus CDS
      CCDS21397.1
      UniProtKB/Swiss-Prot
      P23188
      Related
      ENSMUSP00000113370.2, ENSMUST00000122232.8
      Conserved Domains (4) summary
      cd04059
      Location:113402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638675
      FU; Furin-like repeats
      pfam01483
      Location:484570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80038942..80055188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250821.3XP_011249123.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249123.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    2. XM_011250822.3XP_011249124.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249124.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    3. XM_011250819.4XP_011249121.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249121.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    4. XM_011250818.2XP_011249120.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249120.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    5. XM_030242209.2XP_030098069.1  furin isoform X2

      Conserved Domains (4) summary
      cd04059
      Location:113402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638675
      FU; Furin-like repeats
      pfam01483
      Location:484570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    6. XM_011250820.4XP_011249122.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249122.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    7. XM_030242210.2XP_030098070.1  furin isoform X2

      Conserved Domains (4) summary
      cd04059
      Location:113402
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:638675
      FU; Furin-like repeats
      pfam01483
      Location:484570
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
    8. XM_011250823.1XP_011249125.1  furin isoform X1

      See identical proteins and their annotated locations for XP_011249125.1

      Conserved Domains (4) summary
      cd04059
      Location:113412
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:648685
      FU; Furin-like repeats
      pfam01483
      Location:494580
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:33107
      S8_pro-domain; Peptidase S8 pro-domain
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